A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol

A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol

Abstract Background Combining multimodal lifestyle interventions and disease-modifying drugs (novel or repurposed) could provide novel precision approaches to prevent cognitive impairment. Metformin is a promising candidate in view of the well-established link between type 2 diabetes (T2D) and Alzhe...

Full description

Bibliographic Details
Main Authors: Mariagnese Barbera, Jenni Lehtisalo, Dinithi Perera, Malin Aspö, Mary Cross, Celeste A. De Jager Loots, Emanuela Falaschetti, Naomi Friel, José A. Luchsinger, Hanna Malmberg Gavelin, Markku Peltonen, Geraint Price, Anna Stigsdotter Neely, Charlotta Thunborg, Jaakko Tuomilehto, Francesca Mangialasche, Lefkos Middleton, Tiia Ngandu, Alina Solomon, Miia Kivipelto, on behalf of the MET-FINGER study team
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s
Dementia prevention
Cognitive impairment
Lifestyle-drug combination therapy
Lifestyle intervention
Metformin
Online Access:https://doi.org/10.1186/s13195-023-01355-x

Similar Items

Similar Items