The role of cellular reactive oxygen species in cancer chemotherapy
Abstract Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidative stress and ROS-mediated cell injury in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13046-018-0909-x |
| _version_ | 1818502375845920768 |
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| author | Haotian Yang Rehan M Villani Haolu Wang Matthew J Simpson Michael S Roberts Min Tang Xiaowen Liang |
| author_facet | Haotian Yang Rehan M Villani Haolu Wang Matthew J Simpson Michael S Roberts Min Tang Xiaowen Liang |
| author_sort | Haotian Yang |
| collection | DOAJ |
| description | Abstract Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidative stress and ROS-mediated cell injury in cancer. However, various new therapeutic approaches targeting intracellular ROS levels have yielded mixed results. Since it is impossible to quantitatively detect dynamic ROS levels in tumors during and after chemotherapy in clinical settings, it is of increasing interest to apply mathematical modeling techniques to predict ROS levels for understanding complex tumor biology during chemotherapy. This review outlines the current understanding of the role of ROS in cancer cells during carcinogenesis and during chemotherapy, provides a critical analysis of the methods used for quantitative ROS detection and discusses the application of mathematical modeling in predicting treatment responses. Finally, we provide insights on and perspectives for future development of effective therapeutic ROS-inducing anticancer agents or antioxidants for cancer treatment. |
| first_indexed | 2024-12-10T21:09:25Z |
| format | Article |
| id | doaj.art-cf2fe5ac0c6743d499afe53c051da02a |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-10T21:09:25Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-cf2fe5ac0c6743d499afe53c051da02a2022-12-22T01:33:31ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662018-11-0137111010.1186/s13046-018-0909-xThe role of cellular reactive oxygen species in cancer chemotherapyHaotian Yang0Rehan M Villani1Haolu Wang2Matthew J Simpson3Michael S Roberts4Min Tang5Xiaowen Liang6Therapeutics Research Group, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research InstituteTherapeutics Research Group, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research InstituteTherapeutics Research Group, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research InstituteSchool of Mathematical Sciences, Queensland University of TechnologyTherapeutics Research Group, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research InstituteDepartment of Mathematics and Institute of Natural Sciences, Shanghai Jiao Tong UniversityTherapeutics Research Group, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research InstituteAbstract Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidative stress and ROS-mediated cell injury in cancer. However, various new therapeutic approaches targeting intracellular ROS levels have yielded mixed results. Since it is impossible to quantitatively detect dynamic ROS levels in tumors during and after chemotherapy in clinical settings, it is of increasing interest to apply mathematical modeling techniques to predict ROS levels for understanding complex tumor biology during chemotherapy. This review outlines the current understanding of the role of ROS in cancer cells during carcinogenesis and during chemotherapy, provides a critical analysis of the methods used for quantitative ROS detection and discusses the application of mathematical modeling in predicting treatment responses. Finally, we provide insights on and perspectives for future development of effective therapeutic ROS-inducing anticancer agents or antioxidants for cancer treatment.http://link.springer.com/article/10.1186/s13046-018-0909-xReactive oxygen species (ROS)RedoxCancerChemotherapyROS detectionMathematical modeling |
| spellingShingle | Haotian Yang Rehan M Villani Haolu Wang Matthew J Simpson Michael S Roberts Min Tang Xiaowen Liang The role of cellular reactive oxygen species in cancer chemotherapy Journal of Experimental & Clinical Cancer Research Reactive oxygen species (ROS) Redox Cancer Chemotherapy ROS detection Mathematical modeling |
| title | The role of cellular reactive oxygen species in cancer chemotherapy |
| title_full | The role of cellular reactive oxygen species in cancer chemotherapy |
| title_fullStr | The role of cellular reactive oxygen species in cancer chemotherapy |
| title_full_unstemmed | The role of cellular reactive oxygen species in cancer chemotherapy |
| title_short | The role of cellular reactive oxygen species in cancer chemotherapy |
| title_sort | role of cellular reactive oxygen species in cancer chemotherapy |
| topic | Reactive oxygen species (ROS) Redox Cancer Chemotherapy ROS detection Mathematical modeling |
| url | http://link.springer.com/article/10.1186/s13046-018-0909-x |
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