The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal Dialysis
Background/Aims: The main purpose of the present study was to determine the effect of peritoneal charge barrier dysfunction on hypoalbuminemia during CAPD. Methods: We measured the association of dialysis dose, peritoneal equilibration test (PET) results (ratio of dialysate and plasma creatinine), a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2013-07-01
|
| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/350150 |
| _version_ | 1819016116348911616 |
|---|---|
| author | Guo-Qing Yu Jian Chen Jun-Xia Li |
| author_facet | Guo-Qing Yu Jian Chen Jun-Xia Li |
| author_sort | Guo-Qing Yu |
| collection | DOAJ |
| description | Background/Aims: The main purpose of the present study was to determine the effect of peritoneal charge barrier dysfunction on hypoalbuminemia during CAPD. Methods: We measured the association of dialysis dose, peritoneal equilibration test (PET) results (ratio of dialysate and plasma creatinine), and peritoneal charge barrier index (ratio of pancreatic and salivary α-amylase clearance) on protein loss in 33 patients on maintenance CAPD. All patients were from a single institution and were diagnosed with chronic nephritis (n = 18 cases), diabetic nephropathy (n = 8), hypertension (n = 5), and hepatitis B virus-associated glomerulonephritis (n = 2). Results: The mean (± SD) dialysate protein loss was 4.04 g (± 1.97) per day. Protein loss was positively correlated with dialysis dose (r = 0.438, p = 0.01) but was not significantly correlated with PET results. The mean (± SD) peritoneal charge barrier index was 6.12 (± 21.20) and was inversely correlated with protein loss into the peritoneal dialysate (r = -0.532, p Conclusions: Taken together, our study of CAPD patients indicates that protein loss into the peritoneal dialysate increases with peritoneal dialysis dose and with disruption of the peritoneal charge barrier. |
| first_indexed | 2024-12-21T02:42:31Z |
| format | Article |
| id | doaj.art-cf30ec99f7b34f18a1eae3540dd6ec9d |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-21T02:42:31Z |
| publishDate | 2013-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-cf30ec99f7b34f18a1eae3540dd6ec9d2022-12-21T19:18:39ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432013-07-01374-525225810.1159/000350150350150The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal DialysisGuo-Qing YuJian ChenJun-Xia LiBackground/Aims: The main purpose of the present study was to determine the effect of peritoneal charge barrier dysfunction on hypoalbuminemia during CAPD. Methods: We measured the association of dialysis dose, peritoneal equilibration test (PET) results (ratio of dialysate and plasma creatinine), and peritoneal charge barrier index (ratio of pancreatic and salivary α-amylase clearance) on protein loss in 33 patients on maintenance CAPD. All patients were from a single institution and were diagnosed with chronic nephritis (n = 18 cases), diabetic nephropathy (n = 8), hypertension (n = 5), and hepatitis B virus-associated glomerulonephritis (n = 2). Results: The mean (± SD) dialysate protein loss was 4.04 g (± 1.97) per day. Protein loss was positively correlated with dialysis dose (r = 0.438, p = 0.01) but was not significantly correlated with PET results. The mean (± SD) peritoneal charge barrier index was 6.12 (± 21.20) and was inversely correlated with protein loss into the peritoneal dialysate (r = -0.532, p Conclusions: Taken together, our study of CAPD patients indicates that protein loss into the peritoneal dialysate increases with peritoneal dialysis dose and with disruption of the peritoneal charge barrier.http://www.karger.com/Article/FullText/350150AmylaseCharge barrierContinuous ambulatory peritoneal dialysisHypoalbuminemiaProtein Malnutrition |
| spellingShingle | Guo-Qing Yu Jian Chen Jun-Xia Li The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal Dialysis Kidney & Blood Pressure Research Amylase Charge barrier Continuous ambulatory peritoneal dialysis Hypoalbuminemia Protein Malnutrition |
| title | The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal Dialysis |
| title_full | The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal Dialysis |
| title_fullStr | The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal Dialysis |
| title_full_unstemmed | The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal Dialysis |
| title_short | The Association Between Peritoneal Charge Barrier Dysfunction and Protein Lost During Continuous Ambulatory Peritoneal Dialysis |
| title_sort | association between peritoneal charge barrier dysfunction and protein lost during continuous ambulatory peritoneal dialysis |
| topic | Amylase Charge barrier Continuous ambulatory peritoneal dialysis Hypoalbuminemia Protein Malnutrition |
| url | http://www.karger.com/Article/FullText/350150 |
| work_keys_str_mv | AT guoqingyu theassociationbetweenperitonealchargebarrierdysfunctionandproteinlostduringcontinuousambulatoryperitonealdialysis AT jianchen theassociationbetweenperitonealchargebarrierdysfunctionandproteinlostduringcontinuousambulatoryperitonealdialysis AT junxiali theassociationbetweenperitonealchargebarrierdysfunctionandproteinlostduringcontinuousambulatoryperitonealdialysis AT guoqingyu associationbetweenperitonealchargebarrierdysfunctionandproteinlostduringcontinuousambulatoryperitonealdialysis AT jianchen associationbetweenperitonealchargebarrierdysfunctionandproteinlostduringcontinuousambulatoryperitonealdialysis AT junxiali associationbetweenperitonealchargebarrierdysfunctionandproteinlostduringcontinuousambulatoryperitonealdialysis |