Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review
Nanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/2/205 |
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| author | Maha H. Bashir Nahed S. Korany Dina B. E. Farag Marwa M. S. Abbass Bassant A. Ezzat Radwa H. Hegazy Christof E. Dörfer Karim M. Fawzy El-Sayed |
| author_facet | Maha H. Bashir Nahed S. Korany Dina B. E. Farag Marwa M. S. Abbass Bassant A. Ezzat Radwa H. Hegazy Christof E. Dörfer Karim M. Fawzy El-Sayed |
| author_sort | Maha H. Bashir |
| collection | DOAJ |
| description | Nanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures in the form of hydrogels can create a three-dimensional natural hydrophilic atmosphere pivotal for cell survival and new tissue formation. Thus, hydrogel-based cell distribution and drug administration have evolved as possible options for bone tissue engineering and regeneration. In this context, nanogels or nanohydrogels, created by cross-linking three-dimensional polymer networks, either physically or chemically, with high biocompatibility and mechanical properties were introduced as promising drug delivery systems. The present review highlights the potential of hydrogels and nanopolymers in the field of craniofacial tissue engineering and bone regeneration. |
| first_indexed | 2024-03-11T09:06:20Z |
| format | Article |
| id | doaj.art-cf3192dd21c24fa68030a5fc3a352df7 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T09:06:20Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-cf3192dd21c24fa68030a5fc3a352df72023-11-16T19:21:50ZengMDPI AGBiomolecules2218-273X2023-01-0113220510.3390/biom13020205Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive ReviewMaha H. Bashir0Nahed S. Korany1Dina B. E. Farag2Marwa M. S. Abbass3Bassant A. Ezzat4Radwa H. Hegazy5Christof E. Dörfer6Karim M. Fawzy El-Sayed7Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11553, EgyptClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, 24105 Kiel, GermanyStem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11553, EgyptNanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures in the form of hydrogels can create a three-dimensional natural hydrophilic atmosphere pivotal for cell survival and new tissue formation. Thus, hydrogel-based cell distribution and drug administration have evolved as possible options for bone tissue engineering and regeneration. In this context, nanogels or nanohydrogels, created by cross-linking three-dimensional polymer networks, either physically or chemically, with high biocompatibility and mechanical properties were introduced as promising drug delivery systems. The present review highlights the potential of hydrogels and nanopolymers in the field of craniofacial tissue engineering and bone regeneration.https://www.mdpi.com/2218-273X/13/2/205nanohydrogelscraniofacial defectsmaxillofacial defectstissue engineering |
| spellingShingle | Maha H. Bashir Nahed S. Korany Dina B. E. Farag Marwa M. S. Abbass Bassant A. Ezzat Radwa H. Hegazy Christof E. Dörfer Karim M. Fawzy El-Sayed Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review Biomolecules nanohydrogels craniofacial defects maxillofacial defects tissue engineering |
| title | Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review |
| title_full | Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review |
| title_fullStr | Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review |
| title_full_unstemmed | Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review |
| title_short | Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review |
| title_sort | polymeric nanocomposite hydrogel scaffolds in craniofacial bone regeneration a comprehensive review |
| topic | nanohydrogels craniofacial defects maxillofacial defects tissue engineering |
| url | https://www.mdpi.com/2218-273X/13/2/205 |
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