The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment
The endoplasmic reticulum (ER) is the largest tubular reticular organelle spanning the cell. As the main site of protein synthesis, Ca2+ homeostasis maintenance and lipid metabolism, the ER plays a variety of essential roles in eukaryotic cells, with ER molecular chaperones participate in all these...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1032607/full |
| _version_ | 1811180201329033216 |
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| author | Hongji Sun Mengxue Wu Minxin Wang Xiaomin Zhang Jia Zhu |
| author_facet | Hongji Sun Mengxue Wu Minxin Wang Xiaomin Zhang Jia Zhu |
| author_sort | Hongji Sun |
| collection | DOAJ |
| description | The endoplasmic reticulum (ER) is the largest tubular reticular organelle spanning the cell. As the main site of protein synthesis, Ca2+ homeostasis maintenance and lipid metabolism, the ER plays a variety of essential roles in eukaryotic cells, with ER molecular chaperones participate in all these processes. In recent years, it has been reported that the abnormal expression of ER chaperones often leads to a variety of neurodevelopmental disorders (NDDs), including abnormal neuronal migration, neuronal morphogenesis, and synaptic function. Neuronal development is a complex and precisely regulated process. Currently, the mechanism by which neural development is regulated at the ER level remains under investigation. Therefore, in this work, we reviewed the recent advances in the roles of ER chaperones in neural development and developmental disorders caused by the deficiency of these molecular chaperones. |
| first_indexed | 2024-04-11T06:46:14Z |
| format | Article |
| id | doaj.art-cf32d08993624794bd84acd878308dc6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T06:46:14Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-cf32d08993624794bd84acd878308dc62022-12-22T04:39:20ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.10326071032607The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopmentHongji Sun0Mengxue Wu1Minxin Wang2Xiaomin Zhang3Jia Zhu4School of Basic Medicine, Kunming Medical University, Kunming, Yunnan, ChinaSchool of Basic Medicine, Kunming Medical University, Kunming, Yunnan, ChinaSchool of Basic Medicine, Kunming Medical University, Kunming, Yunnan, ChinaSchool of Basic Medicine, Kunming Medical University, Kunming, Yunnan, ChinaForensic and Pathology Laboratory, Department of Pathology, Institute of Forensic Science, Jiaxing University, Jiaxing, ChinaThe endoplasmic reticulum (ER) is the largest tubular reticular organelle spanning the cell. As the main site of protein synthesis, Ca2+ homeostasis maintenance and lipid metabolism, the ER plays a variety of essential roles in eukaryotic cells, with ER molecular chaperones participate in all these processes. In recent years, it has been reported that the abnormal expression of ER chaperones often leads to a variety of neurodevelopmental disorders (NDDs), including abnormal neuronal migration, neuronal morphogenesis, and synaptic function. Neuronal development is a complex and precisely regulated process. Currently, the mechanism by which neural development is regulated at the ER level remains under investigation. Therefore, in this work, we reviewed the recent advances in the roles of ER chaperones in neural development and developmental disorders caused by the deficiency of these molecular chaperones.https://www.frontiersin.org/articles/10.3389/fnins.2022.1032607/fullneurodevelopmentendoplasmic reticulummolecular chaperoneneuronal migrationneuronal morphogenesissynaptic function |
| spellingShingle | Hongji Sun Mengxue Wu Minxin Wang Xiaomin Zhang Jia Zhu The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment Frontiers in Neuroscience neurodevelopment endoplasmic reticulum molecular chaperone neuronal migration neuronal morphogenesis synaptic function |
| title | The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment |
| title_full | The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment |
| title_fullStr | The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment |
| title_full_unstemmed | The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment |
| title_short | The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment |
| title_sort | regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment |
| topic | neurodevelopment endoplasmic reticulum molecular chaperone neuronal migration neuronal morphogenesis synaptic function |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1032607/full |
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