The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01464-w |
| _version_ | 1819195694788902912 |
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| author | Alexandra Santanach Enrique Blanco Hua Jiang Kelly R. Molloy Miriam Sansó John LaCava Lluis Morey Luciano Di Croce |
| author_facet | Alexandra Santanach Enrique Blanco Hua Jiang Kelly R. Molloy Miriam Sansó John LaCava Lluis Morey Luciano Di Croce |
| author_sort | Alexandra Santanach |
| collection | DOAJ |
| description | In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes. |
| first_indexed | 2024-12-23T02:16:50Z |
| format | Article |
| id | doaj.art-cf337e53504d4dbca5db1c546d985bc4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:16:50Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cf337e53504d4dbca5db1c546d985bc42022-12-21T18:03:39ZengNature PortfolioNature Communications2041-17232017-11-018111110.1038/s41467-017-01464-wThe Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identityAlexandra Santanach0Enrique Blanco1Hua Jiang2Kelly R. Molloy3Miriam Sansó4John LaCava5Lluis Morey6Luciano Di Croce7Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyLaboratory of Cellular and Structural Biology, The Rockefeller UniversityLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller UniversityCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyLaboratory of Cellular and Structural Biology, The Rockefeller UniversityCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyIn mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes.https://doi.org/10.1038/s41467-017-01464-w |
| spellingShingle | Alexandra Santanach Enrique Blanco Hua Jiang Kelly R. Molloy Miriam Sansó John LaCava Lluis Morey Luciano Di Croce The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity Nature Communications |
| title | The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity |
| title_full | The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity |
| title_fullStr | The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity |
| title_full_unstemmed | The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity |
| title_short | The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity |
| title_sort | polycomb group protein cbx6 is an essential regulator of embryonic stem cell identity |
| url | https://doi.org/10.1038/s41467-017-01464-w |
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