Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract
The Celtis iguanaea (Jacq.) Sargent (Cannabaceae) is one of the native species of the Cerrado region of Brazil widely used in folk medicine to treat dyspepsia. The objective of the present study was to evaluate the gastroprotective effect of the Celtis iguanaea (Jacq.) Sargent (HE) hexane leaf extra...
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| Format: | Article |
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Universidade Estadual Paulista
2014-06-01
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| Series: | Revista Brasileira de Plantas Medicinais |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-05722014000200013&lng=en&tlng=en |
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| author | J.L.R. Martins F.B. Sousa J.O. Fajemiroye P.C. Ghedini P.M. Ferreira E.A. Costa |
| author_facet | J.L.R. Martins F.B. Sousa J.O. Fajemiroye P.C. Ghedini P.M. Ferreira E.A. Costa |
| author_sort | J.L.R. Martins |
| collection | DOAJ |
| description | The Celtis iguanaea (Jacq.) Sargent (Cannabaceae) is one of the native species of the Cerrado region of Brazil widely used in folk medicine to treat dyspepsia. The objective of the present study was to evaluate the gastroprotective effect of the Celtis iguanaea (Jacq.) Sargent (HE) hexane leaf extract in the lesion and gastric secretion models.Antiulcerogenic activity of the Celtis iguanaea (HE) hexane leaf extract was observed with the experimental models, such as indomethacin and pyloric ligation-induced gastric ulcers. In order to evaluate the antisecretory activity of this extract, isolated Rana catesbeiana mucosa and pyloric ligation in mice were used. The HE treatment reduced the lesion index of indomethacin and pyloric ligation-induced ulcer. This extract also reduced the gastric acid secretion and total acidity (increasing the gastric pH) in mice. The secretion of H+ was reduced in the basal values (15.58 ± 1.99 µEq H+/g/15 min) when isolated Rana catesbeiana mucosa was incubated with HE. Intraduodenal administration of HE reduced the gastric secretion produced by bethanecol or histamine. The antiulcerogenic and antisecretory efficacy of HE in this study suggest anticholinergic and antihistaminergic mechanism or interruption of intracellular events that are linked to acid secretion. |
| first_indexed | 2024-12-10T10:56:20Z |
| format | Article |
| id | doaj.art-cf34a54034174ed689eab69e974ac219 |
| institution | Directory Open Access Journal |
| issn | 1983-084X |
| language | English |
| last_indexed | 2024-12-10T10:56:20Z |
| publishDate | 2014-06-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Revista Brasileira de Plantas Medicinais |
| spelling | doaj.art-cf34a54034174ed689eab69e974ac2192022-12-22T01:51:53ZengUniversidade Estadual PaulistaRevista Brasileira de Plantas Medicinais1983-084X2014-06-0116225025510.1590/S1516-05722014000200013S1516-05722014000200013Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extractJ.L.R. Martins0F.B. Sousa1J.O. Fajemiroye2P.C. Ghedini3P.M. Ferreira4E.A. Costa5Universidade Federal de GoiásUniversidade Federal de GoiásUniversidade Federal de GoiásUniversidade Federal de GoiásUniversidade Federal de GoiásUniversidade Federal de GoiásThe Celtis iguanaea (Jacq.) Sargent (Cannabaceae) is one of the native species of the Cerrado region of Brazil widely used in folk medicine to treat dyspepsia. The objective of the present study was to evaluate the gastroprotective effect of the Celtis iguanaea (Jacq.) Sargent (HE) hexane leaf extract in the lesion and gastric secretion models.Antiulcerogenic activity of the Celtis iguanaea (HE) hexane leaf extract was observed with the experimental models, such as indomethacin and pyloric ligation-induced gastric ulcers. In order to evaluate the antisecretory activity of this extract, isolated Rana catesbeiana mucosa and pyloric ligation in mice were used. The HE treatment reduced the lesion index of indomethacin and pyloric ligation-induced ulcer. This extract also reduced the gastric acid secretion and total acidity (increasing the gastric pH) in mice. The secretion of H+ was reduced in the basal values (15.58 ± 1.99 µEq H+/g/15 min) when isolated Rana catesbeiana mucosa was incubated with HE. Intraduodenal administration of HE reduced the gastric secretion produced by bethanecol or histamine. The antiulcerogenic and antisecretory efficacy of HE in this study suggest anticholinergic and antihistaminergic mechanism or interruption of intracellular events that are linked to acid secretion.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-05722014000200013&lng=en&tlng=enCeltis iguanaeaatividade anti-ulcerogênicaatividade antisecretóriacerradoextrato hexânico |
| spellingShingle | J.L.R. Martins F.B. Sousa J.O. Fajemiroye P.C. Ghedini P.M. Ferreira E.A. Costa Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract Revista Brasileira de Plantas Medicinais Celtis iguanaea atividade anti-ulcerogênica atividade antisecretória cerrado extrato hexânico |
| title | Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract |
| title_full | Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract |
| title_fullStr | Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract |
| title_full_unstemmed | Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract |
| title_short | Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract |
| title_sort | anti ulcerogenic and antisecretory effects of celtis iguanaea jacq sargent hexane leaf extract |
| topic | Celtis iguanaea atividade anti-ulcerogênica atividade antisecretória cerrado extrato hexânico |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-05722014000200013&lng=en&tlng=en |
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