Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer Treatment

Identification of Natural Compounds as Inhibitors of Pyruvate Kinase M2 for Cancer Treatment

The reliance of tumor cells on aerobic glycolysis is one of the emerging hallmarks of cancer. Pyruvate kinase M2 (PKM2), an important enzyme of glycolytic pathway, is highly expressed in a number of cancer cells. Tumor cells heavily depend on PKM2 to fulfill their divergent energetic and biosyntheti...

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Bibliographic Details
Main Authors: Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tayyaba Sultana, Şevki Adem
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
tumor metabolism
pyruvate kinase M2
phytochemicals
enzymatic assay
Online Access:https://www.mdpi.com/1420-3049/27/20/7113

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