Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis
PURPOSEThis study aims to examine the association between exposure to major ambient air pollutants and the incidence and mortality of lung cancer and some nonlung cancers.METHODSThis meta-analysis used PubMed and EMBASE databases to access published studies that met the eligibility criteria. Primary...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2024-03-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.23.00427 |
| _version_ | 1797249450988535808 |
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| author | Thilagavathi Ramamoorthy Anita Nath Shubhra Singh Stany Mathew Apourv Pant Samvedana Sheela Gurpreet Kaur Krishnan Sathishkumar Prashant Mathur |
| author_facet | Thilagavathi Ramamoorthy Anita Nath Shubhra Singh Stany Mathew Apourv Pant Samvedana Sheela Gurpreet Kaur Krishnan Sathishkumar Prashant Mathur |
| author_sort | Thilagavathi Ramamoorthy |
| collection | DOAJ |
| description | PURPOSEThis study aims to examine the association between exposure to major ambient air pollutants and the incidence and mortality of lung cancer and some nonlung cancers.METHODSThis meta-analysis used PubMed and EMBASE databases to access published studies that met the eligibility criteria. Primary analysis investigated the association between exposure to air pollutants and cancer incidence and mortality. Study quality was assessed using the Newcastle Ottawa Scale. Meta-analysis was conducted using R software.RESULTSThe meta-analysis included 61 studies, of which 53 were cohort studies and eight were case-control studies. Particulate matter 2.5 mm or less in diameter (PM2.5) was the exposure pollutant in half (55.5%), and lung cancer was the most frequently studied cancer in 59% of the studies. A pooled analysis of exposure reported in cohort and case-control studies and cancer incidence demonstrated a significant relationship (relative risk [RR], 1.04 [95% CI, 1.02 to 1.05]; I2, 88.93%; P < .05). A significant association was observed between exposure to pollutants such as PM2.5 (RR, 1.08 [95% CI, 1.04 to 1.12]; I2, 68.52%) and nitrogen dioxide (NO2) (RR, 1.03 [95% CI, 1.01 to 1.05]; I2, 73.52%) and lung cancer incidence. The relationship between exposure to the air pollutants and cancer mortality demonstrated a significant relationship (RR, 1.08 [95% CI, 1.07 to 1.10]; I2, 94.77%; P < .001). Among the four pollutants, PM2.5 (RR, 1.15 [95% CI, 1.08 to 1.22]; I2, 95.33%) and NO2 (RR, 1.05 [95% CI, 1.02 to 1.08]; I2, 89.98%) were associated with lung cancer mortality.CONCLUSIONThe study confirms the association between air pollution exposure and lung cancer incidence and mortality. The meta-analysis results could contribute to community cancer prevention and diagnosis and help inform stakeholders and policymakers in decision making. |
| first_indexed | 2024-04-24T20:30:41Z |
| format | Article |
| id | doaj.art-cf3763bed5be4dd4b06204110d138307 |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-04-24T20:30:41Z |
| publishDate | 2024-03-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-cf3763bed5be4dd4b06204110d1383072024-03-21T19:59:24ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412024-03-011010.1200/GO.23.00427Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-AnalysisThilagavathi Ramamoorthy0Anita Nath1Shubhra Singh2Stany Mathew3Apourv Pant4Samvedana Sheela5Gurpreet Kaur6Krishnan Sathishkumar7Prashant Mathur8Indian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaIndian Council of Medical Research- National Centre for Disease Informatics and Research, Bengaluru, IndiaPURPOSEThis study aims to examine the association between exposure to major ambient air pollutants and the incidence and mortality of lung cancer and some nonlung cancers.METHODSThis meta-analysis used PubMed and EMBASE databases to access published studies that met the eligibility criteria. Primary analysis investigated the association between exposure to air pollutants and cancer incidence and mortality. Study quality was assessed using the Newcastle Ottawa Scale. Meta-analysis was conducted using R software.RESULTSThe meta-analysis included 61 studies, of which 53 were cohort studies and eight were case-control studies. Particulate matter 2.5 mm or less in diameter (PM2.5) was the exposure pollutant in half (55.5%), and lung cancer was the most frequently studied cancer in 59% of the studies. A pooled analysis of exposure reported in cohort and case-control studies and cancer incidence demonstrated a significant relationship (relative risk [RR], 1.04 [95% CI, 1.02 to 1.05]; I2, 88.93%; P < .05). A significant association was observed between exposure to pollutants such as PM2.5 (RR, 1.08 [95% CI, 1.04 to 1.12]; I2, 68.52%) and nitrogen dioxide (NO2) (RR, 1.03 [95% CI, 1.01 to 1.05]; I2, 73.52%) and lung cancer incidence. The relationship between exposure to the air pollutants and cancer mortality demonstrated a significant relationship (RR, 1.08 [95% CI, 1.07 to 1.10]; I2, 94.77%; P < .001). Among the four pollutants, PM2.5 (RR, 1.15 [95% CI, 1.08 to 1.22]; I2, 95.33%) and NO2 (RR, 1.05 [95% CI, 1.02 to 1.08]; I2, 89.98%) were associated with lung cancer mortality.CONCLUSIONThe study confirms the association between air pollution exposure and lung cancer incidence and mortality. The meta-analysis results could contribute to community cancer prevention and diagnosis and help inform stakeholders and policymakers in decision making.https://ascopubs.org/doi/10.1200/GO.23.00427 |
| spellingShingle | Thilagavathi Ramamoorthy Anita Nath Shubhra Singh Stany Mathew Apourv Pant Samvedana Sheela Gurpreet Kaur Krishnan Sathishkumar Prashant Mathur Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis JCO Global Oncology |
| title | Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis |
| title_full | Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis |
| title_fullStr | Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis |
| title_full_unstemmed | Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis |
| title_short | Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis |
| title_sort | assessing the global impact of ambient air pollution on cancer incidence and mortality a comprehensive meta analysis |
| url | https://ascopubs.org/doi/10.1200/GO.23.00427 |
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