Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance
Background: There is an ongoing need for targeted therapy and systemic treatment protocols for papillary thyroid carcinoma (PTC) patients. Yes activated protein-1 (YAP-1) has been found to control many targets of Hippo pathway. Annexin family is a huge family playing many roles in cellular processes...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-01-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | https://mejc.sums.ac.ir/article_48522_078a3b762f457260ecd86ae43c576777.pdf |
| _version_ | 1797976813166657536 |
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| author | Walid Elsayed Ola Harb Ahmed Obaya Dalia Elsayed Loay Gertallah Walid Mawla Ahmed Abd El Fattah |
| author_facet | Walid Elsayed Ola Harb Ahmed Obaya Dalia Elsayed Loay Gertallah Walid Mawla Ahmed Abd El Fattah |
| author_sort | Walid Elsayed |
| collection | DOAJ |
| description | Background: There is an ongoing need for targeted therapy and systemic treatment protocols for papillary thyroid carcinoma (PTC) patients. Yes activated protein-1 (YAP-1) has been found to control many targets of Hippo pathway. Annexin family is a huge family playing many roles in cellular processes. Annexin A10 (ANXA10) is a member of annexin family. Uncoordinated-5D (UNC5D), a recently discovered Unc5 family member which is found in normal tissues and downregulated in cancer cell lines and tissues. Aim of the study was to assess the expression of YAP-1, ANXA10, and UNC5D in PTC and in non-neoplastic tissues of thyroid gland using immunohistochemistry to evaluate their clinical significance and prognostic values in PTC patients.Method: In the present prospective study, we took samples from 60 patients with PTC and 30 samples from non-neoplastic thyroid tissues for YAP-1, ANXA10, and UNC5D immunohistochemistry. All the patients were followed up for assessment of the prognostic, clinical, and pathological of their expression.Results: Upregulation of YAP-1 and ANXA10 in addition to downregulation of UNC5D was found in PTC tissues more than non-neoplastic thyroid tissues. In PTC tissues, there were positive associations between high YAP-1 and ANXA10 expression, low UNC5D expression, tumor size (P = 0.022, 0.011, 0.014), presence of lymph node metastases (P = 0.005, < 0.001, 0.008), and inferior disease-free survival rate (P = 0.003, 0.01, 0.03).Conclusion: Upregulation of YAP-1 and ANXA10 expression and downregulation of UNC5D was associated with bad clincopathological criteria, disease progression, high incidence of disease recurrence, and poor survival. |
| first_indexed | 2024-04-11T04:56:55Z |
| format | Article |
| id | doaj.art-cf37e822846946159c174deab26f7d6c |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-04-11T04:56:55Z |
| publishDate | 2023-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-cf37e822846946159c174deab26f7d6c2022-12-26T09:11:34ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872023-01-01141294010.30476/mejc.2022.89869.155148522Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical SignificanceWalid Elsayed0Ola Harb1Ahmed Obaya2Dalia Elsayed3Loay Gertallah4Walid Mawla5Ahmed Abd El Fattah6Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Medical Oncology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, EgyptBackground: There is an ongoing need for targeted therapy and systemic treatment protocols for papillary thyroid carcinoma (PTC) patients. Yes activated protein-1 (YAP-1) has been found to control many targets of Hippo pathway. Annexin family is a huge family playing many roles in cellular processes. Annexin A10 (ANXA10) is a member of annexin family. Uncoordinated-5D (UNC5D), a recently discovered Unc5 family member which is found in normal tissues and downregulated in cancer cell lines and tissues. Aim of the study was to assess the expression of YAP-1, ANXA10, and UNC5D in PTC and in non-neoplastic tissues of thyroid gland using immunohistochemistry to evaluate their clinical significance and prognostic values in PTC patients.Method: In the present prospective study, we took samples from 60 patients with PTC and 30 samples from non-neoplastic thyroid tissues for YAP-1, ANXA10, and UNC5D immunohistochemistry. All the patients were followed up for assessment of the prognostic, clinical, and pathological of their expression.Results: Upregulation of YAP-1 and ANXA10 in addition to downregulation of UNC5D was found in PTC tissues more than non-neoplastic thyroid tissues. In PTC tissues, there were positive associations between high YAP-1 and ANXA10 expression, low UNC5D expression, tumor size (P = 0.022, 0.011, 0.014), presence of lymph node metastases (P = 0.005, < 0.001, 0.008), and inferior disease-free survival rate (P = 0.003, 0.01, 0.03).Conclusion: Upregulation of YAP-1 and ANXA10 expression and downregulation of UNC5D was associated with bad clincopathological criteria, disease progression, high incidence of disease recurrence, and poor survival.https://mejc.sums.ac.ir/article_48522_078a3b762f457260ecd86ae43c576777.pdfyap-1 proteinanxa10unc5dptcimmunohistochemistryprognosis |
| spellingShingle | Walid Elsayed Ola Harb Ahmed Obaya Dalia Elsayed Loay Gertallah Walid Mawla Ahmed Abd El Fattah Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance Middle East Journal of Cancer yap-1 protein anxa10 unc5d ptc immunohistochemistry prognosis |
| title | Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance |
| title_full | Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance |
| title_fullStr | Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance |
| title_full_unstemmed | Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance |
| title_short | Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance |
| title_sort | expressions of yap 1 anxa10 and unc5d in tissues of papillary thyroid carcinoma prognostic pathological and clinical significance |
| topic | yap-1 protein anxa10 unc5d ptc immunohistochemistry prognosis |
| url | https://mejc.sums.ac.ir/article_48522_078a3b762f457260ecd86ae43c576777.pdf |
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