Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age
Background. Wheezing symptoms are one of the risk factors in young pneumonia patients that often leads to asthma development. Infant pulmonary function test (iPFT) is potentially a useful tool to help identify and manage these high-risk pneumonia patients. Methods. To examine whether patients with w...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-04-01
|
| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X19840357 |
| _version_ | 1818188389772427264 |
|---|---|
| author | Jichang Chen MS Xin Liu MS Wei Du PhD Ruma Srivastava MD Jinjian Fu PhD Min Zheng PhD Jin Zhou MS Eric McGrath MD |
| author_facet | Jichang Chen MS Xin Liu MS Wei Du PhD Ruma Srivastava MD Jinjian Fu PhD Min Zheng PhD Jin Zhou MS Eric McGrath MD |
| author_sort | Jichang Chen MS |
| collection | DOAJ |
| description | Background. Wheezing symptoms are one of the risk factors in young pneumonia patients that often leads to asthma development. Infant pulmonary function test (iPFT) is potentially a useful tool to help identify and manage these high-risk pneumonia patients. Methods. To examine whether patients with wheezing symptoms are more likely to have poorer pulmonary function and treatment outcomes, and also to explore the clinical benefit of iPFT in young pneumonia patients, we conducted a retrospective analysis of 1005 pneumonia inpatients <3 years of age who had undergone iPFT testing in 2016 at Liuzhou Maternity and Child Healthcare Hospital in Guang-Xi, China. Results . We identified from the hospital database 505 pneumonia patients who presented with wheezing and 500 without wheezing. Univariate analysis showed that wheezing symptoms, viral infection, age <1 year, female gender, and prematurity were significantly associated with poorer iPFT results. After adjusting for confounders, patients with wheezing showed significantly poorer pulmonary function. Patients with wheezing had longer length of stay (7.9 ± 3.9 days vs 6.5 ± 2.6 days; P < .001) and lower percent with no residual clinical symptoms at discharge (58% vs 98%; P < .001) when compared with those of non-wheezing patients. In addition, 81% of patients with viral infection as compared with 43% of patients with nonviral infection presented with wheezing symptoms ( P < .001). Conclusion. Wheezing symptoms were associated with poorer iPFT measures and treatment outcomes for pneumonia inpatients <3 years of age. Patients with wheezing had poorer treatment outcomes. iPFT can be useful in assessing and monitoring young patients with high risk of developing asthma or chronic lung disease later in life. |
| first_indexed | 2024-12-11T23:26:09Z |
| format | Article |
| id | doaj.art-cf384dd390804891aa5cf5f6d6b55861 |
| institution | Directory Open Access Journal |
| issn | 2333-794X |
| language | English |
| last_indexed | 2024-12-11T23:26:09Z |
| publishDate | 2019-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj.art-cf384dd390804891aa5cf5f6d6b558612022-12-22T00:46:11ZengSAGE PublishingGlobal Pediatric Health2333-794X2019-04-01610.1177/2333794X19840357Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of AgeJichang Chen MS0Xin Liu MS1Wei Du PhD2Ruma Srivastava MD3Jinjian Fu PhD4Min Zheng PhD5Jin Zhou MS6Eric McGrath MD7Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, ChinaLiuzhou Maternity and Child Healthcare Hospital, Liuzhou, ChinaWayne State University, Detroit, MI, USAWayne State University, Detroit, MI, USALiuzhou Maternity and Child Healthcare Hospital, Liuzhou, ChinaLiuzhou Maternity and Child Healthcare Hospital, Liuzhou, ChinaLiuzhou Maternity and Child Healthcare Hospital, Liuzhou, ChinaWayne State University, Detroit, MI, USABackground. Wheezing symptoms are one of the risk factors in young pneumonia patients that often leads to asthma development. Infant pulmonary function test (iPFT) is potentially a useful tool to help identify and manage these high-risk pneumonia patients. Methods. To examine whether patients with wheezing symptoms are more likely to have poorer pulmonary function and treatment outcomes, and also to explore the clinical benefit of iPFT in young pneumonia patients, we conducted a retrospective analysis of 1005 pneumonia inpatients <3 years of age who had undergone iPFT testing in 2016 at Liuzhou Maternity and Child Healthcare Hospital in Guang-Xi, China. Results . We identified from the hospital database 505 pneumonia patients who presented with wheezing and 500 without wheezing. Univariate analysis showed that wheezing symptoms, viral infection, age <1 year, female gender, and prematurity were significantly associated with poorer iPFT results. After adjusting for confounders, patients with wheezing showed significantly poorer pulmonary function. Patients with wheezing had longer length of stay (7.9 ± 3.9 days vs 6.5 ± 2.6 days; P < .001) and lower percent with no residual clinical symptoms at discharge (58% vs 98%; P < .001) when compared with those of non-wheezing patients. In addition, 81% of patients with viral infection as compared with 43% of patients with nonviral infection presented with wheezing symptoms ( P < .001). Conclusion. Wheezing symptoms were associated with poorer iPFT measures and treatment outcomes for pneumonia inpatients <3 years of age. Patients with wheezing had poorer treatment outcomes. iPFT can be useful in assessing and monitoring young patients with high risk of developing asthma or chronic lung disease later in life.https://doi.org/10.1177/2333794X19840357 |
| spellingShingle | Jichang Chen MS Xin Liu MS Wei Du PhD Ruma Srivastava MD Jinjian Fu PhD Min Zheng PhD Jin Zhou MS Eric McGrath MD Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age Global Pediatric Health |
| title | Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age |
| title_full | Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age |
| title_fullStr | Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age |
| title_full_unstemmed | Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age |
| title_short | Pulmonary Function Testing in Pediatric Pneumonia Patients With Wheezing Younger Than 3 Years of Age |
| title_sort | pulmonary function testing in pediatric pneumonia patients with wheezing younger than 3 years of age |
| url | https://doi.org/10.1177/2333794X19840357 |
| work_keys_str_mv | AT jichangchenms pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage AT xinliums pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage AT weiduphd pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage AT rumasrivastavamd pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage AT jinjianfuphd pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage AT minzhengphd pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage AT jinzhoums pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage AT ericmcgrathmd pulmonaryfunctiontestinginpediatricpneumoniapatientswithwheezingyoungerthan3yearsofage |