Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors
Exertional dyspnoea is among the dominant symptoms in patients with chronic heart failure and progresses relentlessly as the disease advances, leading to reduced ability to function and engage in activities of daily living. Effective management of this disabling symptom awaits a better understanding...
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2016-09-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/25/141/317.full |
| _version_ | 1819241096901820416 |
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| author | Bruno-Pierre Dubé Piergiuseppe Agostoni Pierantonio Laveneziana |
| author_facet | Bruno-Pierre Dubé Piergiuseppe Agostoni Pierantonio Laveneziana |
| author_sort | Bruno-Pierre Dubé |
| collection | DOAJ |
| description | Exertional dyspnoea is among the dominant symptoms in patients with chronic heart failure and progresses relentlessly as the disease advances, leading to reduced ability to function and engage in activities of daily living. Effective management of this disabling symptom awaits a better understanding of its underlying physiology. Cardiovascular factors are believed to play a major role in dyspnoea in heart failure patients. However, despite pharmacological interventions, such as vasodilators or inotropes that improve central haemodynamics, patients with heart failure still complain of exertional dyspnoea. Clearly, dyspnoea is not determined by cardiac factors alone, but likely depends on complex, integrated cardio-pulmonary interactions. A growing body of evidence suggests that excessively increased ventilatory demand and abnormal “restrictive” constraints on tidal volume expansion with development of critical mechanical limitation of ventilation, contribute to exertional dyspnoea in heart failure. This article will offer new insights into the pathophysiological mechanisms of exertional dyspnoea in patients with chronic heart failure by exploring the potential role of the various constituents of the physiological response to exercise and particularly the role of abnormal ventilatory and respiratory mechanics responses to exercise in the perception of dyspnoea in patients with heart failure. |
| first_indexed | 2024-12-23T14:18:29Z |
| format | Article |
| id | doaj.art-cf39356bee434921b9f1d558cda63b11 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-12-23T14:18:29Z |
| publishDate | 2016-09-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-cf39356bee434921b9f1d558cda63b112022-12-21T17:43:52ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172016-09-012514131733210.1183/16000617.0048-20160048-2016Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factorsBruno-Pierre Dubé0Piergiuseppe Agostoni1Pierantonio Laveneziana2 Dépt de Médecine, Service de Pneumologie, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada Centro Cardiologico Monzino, IRCCS, Milan, Italy Sorbonne Universités, UPMC Université Paris 06, INSERM, UMRS 1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France Exertional dyspnoea is among the dominant symptoms in patients with chronic heart failure and progresses relentlessly as the disease advances, leading to reduced ability to function and engage in activities of daily living. Effective management of this disabling symptom awaits a better understanding of its underlying physiology. Cardiovascular factors are believed to play a major role in dyspnoea in heart failure patients. However, despite pharmacological interventions, such as vasodilators or inotropes that improve central haemodynamics, patients with heart failure still complain of exertional dyspnoea. Clearly, dyspnoea is not determined by cardiac factors alone, but likely depends on complex, integrated cardio-pulmonary interactions. A growing body of evidence suggests that excessively increased ventilatory demand and abnormal “restrictive” constraints on tidal volume expansion with development of critical mechanical limitation of ventilation, contribute to exertional dyspnoea in heart failure. This article will offer new insights into the pathophysiological mechanisms of exertional dyspnoea in patients with chronic heart failure by exploring the potential role of the various constituents of the physiological response to exercise and particularly the role of abnormal ventilatory and respiratory mechanics responses to exercise in the perception of dyspnoea in patients with heart failure.http://err.ersjournals.com/content/25/141/317.full |
| spellingShingle | Bruno-Pierre Dubé Piergiuseppe Agostoni Pierantonio Laveneziana Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors European Respiratory Review |
| title | Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors |
| title_full | Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors |
| title_fullStr | Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors |
| title_full_unstemmed | Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors |
| title_short | Exertional dyspnoea in chronic heart failure: the role of the lung and respiratory mechanical factors |
| title_sort | exertional dyspnoea in chronic heart failure the role of the lung and respiratory mechanical factors |
| url | http://err.ersjournals.com/content/25/141/317.full |
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