Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China
Objectives To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status.Design Cross-sectional survey study.Setting Haematology department of...
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| Format: | Article |
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BMJ Publishing Group
2023-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/3/e066467.full |
| _version_ | 1797744357846024192 |
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| author | Tingting Cai Changrong Yuan Xin Liang Tingting Zhou Chunfang Yu Ning Zeng Guihua Pan Wei Ouyang |
| author_facet | Tingting Cai Changrong Yuan Xin Liang Tingting Zhou Chunfang Yu Ning Zeng Guihua Pan Wei Ouyang |
| author_sort | Tingting Cai |
| collection | DOAJ |
| description | Objectives To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status.Design Cross-sectional survey study.Setting Haematology department of two tertiary hospitals affiliated with Guilin Medical University in China.Participants Using a convenience sampling method, questionnaires were distributed to patients with MM visiting two hospitals in Guilin, China.Interventions The patients were categorised into subgroups based on cancer-related symptoms using a latent class analysis. An analysis of covariance was performed to examine how demographic and clinical characteristics and functional status differed among the subgroups.Results In total, 216 patients completed the survey, with an average age of 60.3 years. A three-class solution was identified: low symptom burden group (class 1, 36.6%), moderate symptom burden group (class 2, 34.2%) and high symptom burden group (class 3, 29.2%). Patients with low monthly family income (OR=3.14, p=0.010) and complications of MM bone disease (OR=2.95, p=0.029) were more likely to belong to class 2. The predictors of high-burden symptoms were treated with painkillers, antidepressants or hypnotic drugs (OR=3.68, p=0.012) and <5000 daily step counts (OR=2.52, p=0.039) in class 3. Functional status was correlated with symptom burden, with patients in classes 3 and 1 reporting significantly higher and lower functional status, respectively (p<0.05).Conclusions Patients with MM experienced varying degrees of symptoms during treatment. The identification of patients with high symptom burden management should focus on the assessment of demographic and clinical characteristics, in addition to functional status. |
| first_indexed | 2024-03-12T15:08:37Z |
| format | Article |
| id | doaj.art-cf3a4a22bf7649f1a9025400a4aebbaa |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-12T15:08:37Z |
| publishDate | 2023-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-cf3a4a22bf7649f1a9025400a4aebbaa2023-08-12T01:25:07ZengBMJ Publishing GroupBMJ Open2044-60552023-03-0113310.1136/bmjopen-2022-066467Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in ChinaTingting Cai0Changrong Yuan1Xin Liang2Tingting Zhou3Chunfang Yu4Ning Zeng5Guihua Pan6Wei Ouyang7Fudan University School of Nursing, Shanghai, ChinaFudan University School of Nursing, Shanghai, ChinaGuangxi Normal University, Guilin, Guangxi, ChinaFudan University School of Nursing, Shanghai, ChinaDepartment of Hematopathology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Nephrology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Nephrology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Nursing, Peking Union Medical College Hospital, Beijing, ChinaObjectives To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status.Design Cross-sectional survey study.Setting Haematology department of two tertiary hospitals affiliated with Guilin Medical University in China.Participants Using a convenience sampling method, questionnaires were distributed to patients with MM visiting two hospitals in Guilin, China.Interventions The patients were categorised into subgroups based on cancer-related symptoms using a latent class analysis. An analysis of covariance was performed to examine how demographic and clinical characteristics and functional status differed among the subgroups.Results In total, 216 patients completed the survey, with an average age of 60.3 years. A three-class solution was identified: low symptom burden group (class 1, 36.6%), moderate symptom burden group (class 2, 34.2%) and high symptom burden group (class 3, 29.2%). Patients with low monthly family income (OR=3.14, p=0.010) and complications of MM bone disease (OR=2.95, p=0.029) were more likely to belong to class 2. The predictors of high-burden symptoms were treated with painkillers, antidepressants or hypnotic drugs (OR=3.68, p=0.012) and <5000 daily step counts (OR=2.52, p=0.039) in class 3. Functional status was correlated with symptom burden, with patients in classes 3 and 1 reporting significantly higher and lower functional status, respectively (p<0.05).Conclusions Patients with MM experienced varying degrees of symptoms during treatment. The identification of patients with high symptom burden management should focus on the assessment of demographic and clinical characteristics, in addition to functional status.https://bmjopen.bmj.com/content/13/3/e066467.full |
| spellingShingle | Tingting Cai Changrong Yuan Xin Liang Tingting Zhou Chunfang Yu Ning Zeng Guihua Pan Wei Ouyang Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China BMJ Open |
| title | Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China |
| title_full | Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China |
| title_fullStr | Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China |
| title_full_unstemmed | Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China |
| title_short | Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China |
| title_sort | classification of symptom subtypes in patients with multiple myeloma during treatment a cross sectional survey study in china |
| url | https://bmjopen.bmj.com/content/13/3/e066467.full |
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