Metaplastic breast carcinoma with osteogenic component
Metaplastic breast carcinomas (MBC) are rare primary breast malignancies characterized by the co-existence of carcinoma with non-epithelial cellular elements. They can be classified as monophasic spindle cell (sarcomatoid) carcinoma, biphasic carcinosarcoma, adenocarcinoma with divergent stromal dif...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Saudi Journal of Medicine and Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sjmms.net/article.asp?issn=1658-631X;year=2014;volume=2;issue=2;spage=113;epage=116;aulast=Abdel |
| _version_ | 1817992675438100480 |
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| author | Maha SA Abdel Hadi Maha Al-Madi Thamer Wahba Khalid Ghallab Ali M Al-Amri |
| author_facet | Maha SA Abdel Hadi Maha Al-Madi Thamer Wahba Khalid Ghallab Ali M Al-Amri |
| author_sort | Maha SA Abdel Hadi |
| collection | DOAJ |
| description | Metaplastic breast carcinomas (MBC) are rare primary breast malignancies characterized by the co-existence of carcinoma with non-epithelial cellular elements. They can be classified as monophasic spindle cell (sarcomatoid) carcinoma, biphasic carcinosarcoma, adenocarcinoma with divergent stromal differentiation (osseous, chondroid and rarely rhabdoid) as well as adenosquamous and pure squamous cell carcinomas. Nearly all reports portrait women in their forties or older, yet younger affected females in their twenties have been reported. The usual presentation included firm painless breast mass ranging between 1.4 and 14 cm in diameter, with no evidence of loco-regional or distal metastasis. Mammary osteosarcomas are aggressive tumors with a propensity for blood-borne rather than lymphatic spread. Metastatic disease expected to develop at a mean of 10.5 and 14.5 months from the initial diagnosis and demise followed within 20 months of the onset of metastasis. MBC remains a rare entity with poor response to both chemo-radiotherapy, histological diagnosis is challenging yet it is the main stay in outlining the management. The surgical option remains the only successful current treatment in the form of simple Mastectomy to achieve negative margins sparing the patients axillary node dissection. |
| first_indexed | 2024-04-14T01:29:23Z |
| format | Article |
| id | doaj.art-cf3ad86a930c455c9af33a534d416953 |
| institution | Directory Open Access Journal |
| issn | 1658-631X |
| language | English |
| last_indexed | 2024-04-14T01:29:23Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Medicine and Medical Sciences |
| spelling | doaj.art-cf3ad86a930c455c9af33a534d4169532022-12-22T02:20:15ZengWolters Kluwer Medknow PublicationsSaudi Journal of Medicine and Medical Sciences1658-631X2014-01-012211311610.4103/1658-631X.137008Metaplastic breast carcinoma with osteogenic componentMaha SA Abdel HadiMaha Al-MadiThamer WahbaKhalid GhallabAli M Al-AmriMetaplastic breast carcinomas (MBC) are rare primary breast malignancies characterized by the co-existence of carcinoma with non-epithelial cellular elements. They can be classified as monophasic spindle cell (sarcomatoid) carcinoma, biphasic carcinosarcoma, adenocarcinoma with divergent stromal differentiation (osseous, chondroid and rarely rhabdoid) as well as adenosquamous and pure squamous cell carcinomas. Nearly all reports portrait women in their forties or older, yet younger affected females in their twenties have been reported. The usual presentation included firm painless breast mass ranging between 1.4 and 14 cm in diameter, with no evidence of loco-regional or distal metastasis. Mammary osteosarcomas are aggressive tumors with a propensity for blood-borne rather than lymphatic spread. Metastatic disease expected to develop at a mean of 10.5 and 14.5 months from the initial diagnosis and demise followed within 20 months of the onset of metastasis. MBC remains a rare entity with poor response to both chemo-radiotherapy, histological diagnosis is challenging yet it is the main stay in outlining the management. The surgical option remains the only successful current treatment in the form of simple Mastectomy to achieve negative margins sparing the patients axillary node dissection.http://www.sjmms.net/article.asp?issn=1658-631X;year=2014;volume=2;issue=2;spage=113;epage=116;aulast=AbdelBreastosteogenicsarcomacarcinoma |
| spellingShingle | Maha SA Abdel Hadi Maha Al-Madi Thamer Wahba Khalid Ghallab Ali M Al-Amri Metaplastic breast carcinoma with osteogenic component Saudi Journal of Medicine and Medical Sciences Breast osteogenic sarcoma carcinoma |
| title | Metaplastic breast carcinoma with osteogenic component |
| title_full | Metaplastic breast carcinoma with osteogenic component |
| title_fullStr | Metaplastic breast carcinoma with osteogenic component |
| title_full_unstemmed | Metaplastic breast carcinoma with osteogenic component |
| title_short | Metaplastic breast carcinoma with osteogenic component |
| title_sort | metaplastic breast carcinoma with osteogenic component |
| topic | Breast osteogenic sarcoma carcinoma |
| url | http://www.sjmms.net/article.asp?issn=1658-631X;year=2014;volume=2;issue=2;spage=113;epage=116;aulast=Abdel |
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