The importance of apoptosis for immune regulation in Chagas disease
Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2009-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900033 |
| _version_ | 1797712699826634752 |
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| author | George A DosReis Marcela F Lopes |
| author_facet | George A DosReis Marcela F Lopes |
| author_sort | George A DosReis |
| collection | DOAJ |
| description | Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression. |
| first_indexed | 2024-03-12T07:24:37Z |
| format | Article |
| id | doaj.art-cf3c6713eb834120a504c89d2b3686a5 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:24:37Z |
| publishDate | 2009-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-cf3c6713eb834120a504c89d2b3686a52023-09-02T22:11:06ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-07-0110425926210.1590/S0074-02762009000900033The importance of apoptosis for immune regulation in Chagas diseaseGeorge A DosReisMarcela F LopesHost cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900033apoptosislymphocytesphagocytosiscytokinesTrypanosoma cruzi |
| spellingShingle | George A DosReis Marcela F Lopes The importance of apoptosis for immune regulation in Chagas disease Memorias do Instituto Oswaldo Cruz apoptosis lymphocytes phagocytosis cytokines Trypanosoma cruzi |
| title | The importance of apoptosis for immune regulation in Chagas disease |
| title_full | The importance of apoptosis for immune regulation in Chagas disease |
| title_fullStr | The importance of apoptosis for immune regulation in Chagas disease |
| title_full_unstemmed | The importance of apoptosis for immune regulation in Chagas disease |
| title_short | The importance of apoptosis for immune regulation in Chagas disease |
| title_sort | importance of apoptosis for immune regulation in chagas disease |
| topic | apoptosis lymphocytes phagocytosis cytokines Trypanosoma cruzi |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900033 |
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