CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW)
Ovarian cancer (OC) is one of the most common malignant tumors of the reproductive system. The five-year survival rate is extremely low. This disease is difficult to verify due to lack of pathognomonic symptoms and timely diagnosis. The key issue to increase survival in ovarian cancer is finding new...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2015-04-01
|
| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/425 |
| _version_ | 1797876032819167232 |
|---|---|
| author | O. V. Makarov S. A. Moshkovskiy M. A. Karpova M. R. Narimanova |
| author_facet | O. V. Makarov S. A. Moshkovskiy M. A. Karpova M. R. Narimanova |
| author_sort | O. V. Makarov |
| collection | DOAJ |
| description | Ovarian cancer (OC) is one of the most common malignant tumors of the reproductive system. The five-year survival rate is extremely low. This disease is difficult to verify due to lack of pathognomonic symptoms and timely diagnosis. The key issue to increase survival in ovarian cancer is finding new methods for early diagnosis. Thus, the development of new methods for diagnosis of ovarian cancer is one of the most urgent problems in modern oncology. The basic approach in this matter is searching for new biomarkers of ovarian cancer, which will be characterized by such concepts as sensitivity and specificity. Biomarkers present in modern oncology, including CA-125, have insufficient specificity and have low sensitivity. The advantage of using a combination of several diagnostic biomarkers instead of one or panels of markers has been proved. Modern proteomic technologies such as two-dimensional electrophoresis, mass spectrometric methods are a valuable tool for finding new biomarkers for various malignancies, particularly ovarian cancer. The best results are achieved by using SELDI-TOF technology (Surface-enhanced laser desorption/ionization time-of-flight), combining the use of chromatographic protein chips with mass spectrometric detection. Serum amyloid A1 deserves the greatest attention between all of the biomarkers identified using mass spectrometric methods, as its ability to have a direct influence on the development of the tumor has been proved. Also its increase by hundreds of times during the disease has been found compared to the other candidate biomarkers identified by mass spectrometry. The main characteristics of serum amyloid 1A have been analyzed and found as one of the most promising markers for the combined determination for prompt diagnosis of ovarian cancer. |
| first_indexed | 2024-04-10T01:56:53Z |
| format | Article |
| id | doaj.art-cf3db22cda334007b1a7c26653d98c1f |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:56:53Z |
| publishDate | 2015-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-cf3db22cda334007b1a7c26653d98c1f2023-03-13T08:44:35ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272015-04-01111768210.17650/1994-4098-2015-1-76-82441CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW)O. V. Makarov0S. A. Moshkovskiy1M. A. Karpova2M. R. Narimanova3ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; Россия, 117997, Москва, ул. Островитянова, 1ФГБНУ «Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича»; Россия, 119121, Москва, ул. Погодинская, 10ФГБНУ «Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича»; Россия, 119121, Москва, ул. Погодинская, 10ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России; Россия, 117997, Москва, ул. Островитянова, 1Ovarian cancer (OC) is one of the most common malignant tumors of the reproductive system. The five-year survival rate is extremely low. This disease is difficult to verify due to lack of pathognomonic symptoms and timely diagnosis. The key issue to increase survival in ovarian cancer is finding new methods for early diagnosis. Thus, the development of new methods for diagnosis of ovarian cancer is one of the most urgent problems in modern oncology. The basic approach in this matter is searching for new biomarkers of ovarian cancer, which will be characterized by such concepts as sensitivity and specificity. Biomarkers present in modern oncology, including CA-125, have insufficient specificity and have low sensitivity. The advantage of using a combination of several diagnostic biomarkers instead of one or panels of markers has been proved. Modern proteomic technologies such as two-dimensional electrophoresis, mass spectrometric methods are a valuable tool for finding new biomarkers for various malignancies, particularly ovarian cancer. The best results are achieved by using SELDI-TOF technology (Surface-enhanced laser desorption/ionization time-of-flight), combining the use of chromatographic protein chips with mass spectrometric detection. Serum amyloid A1 deserves the greatest attention between all of the biomarkers identified using mass spectrometric methods, as its ability to have a direct influence on the development of the tumor has been proved. Also its increase by hundreds of times during the disease has been found compared to the other candidate biomarkers identified by mass spectrometry. The main characteristics of serum amyloid 1A have been analyzed and found as one of the most promising markers for the combined determination for prompt diagnosis of ovarian cancer.https://ojrs.abvpress.ru/ojrs/article/view/425рак яичниковранняя диагностикабиомаркерпротеомикамасс-спектрометриядвумерный электрофорезбелковые чипысывороточный амилоид а1 |
| spellingShingle | O. V. Makarov S. A. Moshkovskiy M. A. Karpova M. R. Narimanova CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW) Опухоли женской репродуктивной системы рак яичников ранняя диагностика биомаркер протеомика масс-спектрометрия двумерный электрофорез белковые чипы сывороточный амилоид а1 |
| title | CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW) |
| title_full | CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW) |
| title_fullStr | CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW) |
| title_full_unstemmed | CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW) |
| title_short | CURRENT STATUS OF PROBLEM OF EARLY DIAGNOSIS OF OVARIAN CANCER AND ITS SOLUTIONS (LITERATURE REVIEW) |
| title_sort | current status of problem of early diagnosis of ovarian cancer and its solutions literature review |
| topic | рак яичников ранняя диагностика биомаркер протеомика масс-спектрометрия двумерный электрофорез белковые чипы сывороточный амилоид а1 |
| url | https://ojrs.abvpress.ru/ojrs/article/view/425 |
| work_keys_str_mv | AT ovmakarov currentstatusofproblemofearlydiagnosisofovariancanceranditssolutionsliteraturereview AT samoshkovskiy currentstatusofproblemofearlydiagnosisofovariancanceranditssolutionsliteraturereview AT makarpova currentstatusofproblemofearlydiagnosisofovariancanceranditssolutionsliteraturereview AT mrnarimanova currentstatusofproblemofearlydiagnosisofovariancanceranditssolutionsliteraturereview |