Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm
The outburst of inflammatory response and hypercoagulability are among the factors contributing to increased mortality in severe COVID-19 cases. Pentoxifylline (PTX), a xanthine-derived drug registered for the treatment of vascular claudication, has been reported to display broad-spectrum anti-infla...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/22/5305 |
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| author | Wiktoria Feret Magdalena Nalewajska Łukasz Wojczyński Wojciech Witkiewicz Patrycja Kłos Violetta Dziedziejko Andrzej Pawlik |
| author_facet | Wiktoria Feret Magdalena Nalewajska Łukasz Wojczyński Wojciech Witkiewicz Patrycja Kłos Violetta Dziedziejko Andrzej Pawlik |
| author_sort | Wiktoria Feret |
| collection | DOAJ |
| description | The outburst of inflammatory response and hypercoagulability are among the factors contributing to increased mortality in severe COVID-19 cases. Pentoxifylline (PTX), a xanthine-derived drug registered for the treatment of vascular claudication, has been reported to display broad-spectrum anti-inflammatory and immunomodulatory properties via adenosine A2A receptor (A2AR)-related mechanisms, in parallel to its rheological actions. Prior studies have indicated the efficacy of PTX in the treatment of various pulmonary diseases, including the management of acute respiratory distress syndrome of infectious causes. Therefore, PTX has been proposed to have potential benefits in the treatment of SARS-CoV-2 symptoms, as well as its complications. The aim of this review is to discuss available knowledge regarding the role of PTX as a complementary therapeutic in SARS-CoV-2. |
| first_indexed | 2024-03-10T05:24:04Z |
| format | Article |
| id | doaj.art-cf4240f217e4421e845f64298641d07c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:24:04Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cf4240f217e4421e845f64298641d07c2023-11-22T23:49:27ZengMDPI AGJournal of Clinical Medicine2077-03832021-11-011022530510.3390/jcm10225305Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine StormWiktoria Feret0Magdalena Nalewajska1Łukasz Wojczyński2Wojciech Witkiewicz3Patrycja Kłos4Violetta Dziedziejko5Andrzej Pawlik6Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Cardiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandThe outburst of inflammatory response and hypercoagulability are among the factors contributing to increased mortality in severe COVID-19 cases. Pentoxifylline (PTX), a xanthine-derived drug registered for the treatment of vascular claudication, has been reported to display broad-spectrum anti-inflammatory and immunomodulatory properties via adenosine A2A receptor (A2AR)-related mechanisms, in parallel to its rheological actions. Prior studies have indicated the efficacy of PTX in the treatment of various pulmonary diseases, including the management of acute respiratory distress syndrome of infectious causes. Therefore, PTX has been proposed to have potential benefits in the treatment of SARS-CoV-2 symptoms, as well as its complications. The aim of this review is to discuss available knowledge regarding the role of PTX as a complementary therapeutic in SARS-CoV-2.https://www.mdpi.com/2077-0383/10/22/5305COVID-19SARS-CoV-2cytokine stormcytokinespentoxifyllinepneumonia |
| spellingShingle | Wiktoria Feret Magdalena Nalewajska Łukasz Wojczyński Wojciech Witkiewicz Patrycja Kłos Violetta Dziedziejko Andrzej Pawlik Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm Journal of Clinical Medicine COVID-19 SARS-CoV-2 cytokine storm cytokines pentoxifylline pneumonia |
| title | Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm |
| title_full | Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm |
| title_fullStr | Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm |
| title_full_unstemmed | Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm |
| title_short | Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm |
| title_sort | pentoxifylline as a potential adjuvant therapy for covid 19 impeding the burden of the cytokine storm |
| topic | COVID-19 SARS-CoV-2 cytokine storm cytokines pentoxifylline pneumonia |
| url | https://www.mdpi.com/2077-0383/10/22/5305 |
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