Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges
Here, in a longitudinal cohort of 1245 hospital care workers and 146 nursing home residents, the authors find that a large inter-individual variation in anti-spike antibody levels after one dose of BNT162b2mRNA vaccine is partially explained by age, sex, previous exposure, and treatments, while the...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27761-z |
| _version_ | 1819006833423024128 |
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| author | João Faro-Viana Marie-Louise Bergman Lígia A. Gonçalves Nádia Duarte Teresa P. Coutinho Patrícia C. Borges Christian Diwo Rute Castro Paula Matoso Vanessa Malheiro Ana Brennand Lindsay Kosack Onome Akpogheneta João M. Figueira Conceição Cardoso Ana M. Casaca Paula M. Alves Telmo Nunes Carlos Penha-Gonçalves Jocelyne Demengeot |
| author_facet | João Faro-Viana Marie-Louise Bergman Lígia A. Gonçalves Nádia Duarte Teresa P. Coutinho Patrícia C. Borges Christian Diwo Rute Castro Paula Matoso Vanessa Malheiro Ana Brennand Lindsay Kosack Onome Akpogheneta João M. Figueira Conceição Cardoso Ana M. Casaca Paula M. Alves Telmo Nunes Carlos Penha-Gonçalves Jocelyne Demengeot |
| author_sort | João Faro-Viana |
| collection | DOAJ |
| description | Here, in a longitudinal cohort of 1245 hospital care workers and 146 nursing home residents, the authors find that a large inter-individual variation in anti-spike antibody levels after one dose of BNT162b2mRNA vaccine is partially explained by age, sex, previous exposure, and treatments, while the 2nd dose is required to reach sero-conversion at the population level. |
| first_indexed | 2024-12-21T00:14:58Z |
| format | Article |
| id | doaj.art-cf463c30cb5c4ebca7bfc8987cfe0b96 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T00:14:58Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cf463c30cb5c4ebca7bfc8987cfe0b962022-12-21T19:22:16ZengNature PortfolioNature Communications2041-17232022-01-011311810.1038/s41467-021-27761-zPopulation homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age rangesJoão Faro-Viana0Marie-Louise Bergman1Lígia A. Gonçalves2Nádia Duarte3Teresa P. Coutinho4Patrícia C. Borges5Christian Diwo6Rute Castro7Paula Matoso8Vanessa Malheiro9Ana Brennand10Lindsay Kosack11Onome Akpogheneta12João M. Figueira13Conceição Cardoso14Ana M. Casaca15Paula M. Alves16Telmo Nunes17Carlos Penha-Gonçalves18Jocelyne Demengeot19CHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia ClínicaIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaCIISA, Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of LisbonIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaIBET, Instituto de Biologia Experimental e TecnológicaIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaCHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia ClínicaCHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia ClínicaCHLO, Centro Hospitalar de Lisboa Ocidental, Serviço de Patologia ClínicaIBET, Instituto de Biologia Experimental e TecnológicaCIISA, Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of LisbonIGC, Instituto Gulbenkian de CiênciaIGC, Instituto Gulbenkian de CiênciaHere, in a longitudinal cohort of 1245 hospital care workers and 146 nursing home residents, the authors find that a large inter-individual variation in anti-spike antibody levels after one dose of BNT162b2mRNA vaccine is partially explained by age, sex, previous exposure, and treatments, while the 2nd dose is required to reach sero-conversion at the population level.https://doi.org/10.1038/s41467-021-27761-z |
| spellingShingle | João Faro-Viana Marie-Louise Bergman Lígia A. Gonçalves Nádia Duarte Teresa P. Coutinho Patrícia C. Borges Christian Diwo Rute Castro Paula Matoso Vanessa Malheiro Ana Brennand Lindsay Kosack Onome Akpogheneta João M. Figueira Conceição Cardoso Ana M. Casaca Paula M. Alves Telmo Nunes Carlos Penha-Gonçalves Jocelyne Demengeot Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges Nature Communications |
| title | Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges |
| title_full | Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges |
| title_fullStr | Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges |
| title_full_unstemmed | Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges |
| title_short | Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges |
| title_sort | population homogeneity for the antibody response to covid 19 bnt162b2 comirnaty vaccine is only reached after the second dose across all adult age ranges |
| url | https://doi.org/10.1038/s41467-021-27761-z |
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