Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity

Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity

Abstract Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence p...

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Bibliographic Details
Main Authors: Isabel Baenas, Romina Miranda-Olivos, Roser Granero, Neus Solé-Morata, Isabel Sánchez, Antoni Pastor, Amparo del Pino-Gutiérrez, Ester Codina, Francisco J. Tinahones, José A. Fernández-Formoso, Núria Vilarrasa, Fernando Guerrero-Pérez, Rafael Lopez-Urdiales, Núria Virgili, Carles Soriano-Mas, Susana Jiménez-Murcia, Rafael de la Torre, Fernando Fernández-Aranda
Format: Article
Language:English
Published: Cambridge University Press 2023-01-01
Series:European Psychiatry
Subjects:
2-arachidonoylglycerol
anandamide
eating disorders
endocannabinoids
obesity
Online Access:https://www.cambridge.org/core/product/identifier/S0924933823024112/type/journal_article
Description
Summary:Abstract Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence pathophysiology. Then, we aimed to analyze fasting AEA and 2-AG plasma concentrations among individuals with EWC (i.e., anorexia nervosa [AN] and obesity with and without eating disorders [EDs]) compared with healthy controls (HCs), and its association with clinical variables and body mass index (BMI). Methods The sample included 113 adult women. Fifty-seven belonged to the obesity group, 37 without EDs (OB-ED) and 20 with ED (OB+ED classified within the binge spectrum disorders), 27 individuals from the AN group, and 29 from the HC group. Peripheral blood samples, several clinical variables, and BMI were evaluated. Results Unlike 2-AG, AEA concentrations showed significant differences between groups (p < 0.001). Increased AEA was observed in the OB-ED and OB+ED compared with both HC and AN group, respectively. Likewise, AEA was differentially associated with emotional dysregulation, general psychopathology, food addiction, and BMI in all clinical groups. Conclusions These results support the interaction between biological and clinical factors contributing to delineating vulnerability pathways in EWC that could help fit personalized therapeutic approaches.
ISSN:0924-9338
1778-3585

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