Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52)
Polychlorinated biphenyls (PCBs) were used extensively in building materials, including those used in schools. PCBs accumulate in fat, and exposure to PCBs is associated with the development of cancer, neurodevelopmental disorders, cardiovascular disease, obesity, and diabetes. The non-dioxin-like P...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340923005164 |
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| author | Francoise A. Gourronc Michael S. Chimenti Hans-Joachim Lehmler James A. Ankrum Aloysius J. Klingelhutz |
| author_facet | Francoise A. Gourronc Michael S. Chimenti Hans-Joachim Lehmler James A. Ankrum Aloysius J. Klingelhutz |
| author_sort | Francoise A. Gourronc |
| collection | DOAJ |
| description | Polychlorinated biphenyls (PCBs) were used extensively in building materials, including those used in schools. PCBs accumulate in fat, and exposure to PCBs is associated with the development of cancer, neurodevelopmental disorders, cardiovascular disease, obesity, and diabetes. The non-dioxin-like PCB congener, PCB52 (2,2′,5,5′-tetrachlorobiphenyl), is found at one of the highest levels of any congener in school air. PCB52 is oxidized in the liver to hydroxylated forms, mainly 4-OH-PCB52 (2,2’,5,5’-tetrachlorobiphenyl-4-ol). In a previous study, we reported on RNAseq data generated from exposure of human preadipocytes to the dioxin-like PCB congener, PCB126. In this new dataset, we used identical techniques to examine alterations in gene transcript levels in human preadipocytes exposed to PCB52 or 4-OH-PCB52 over a time course. This updated set of data provides a comprehensive transcriptional profile of changes that occur in preadipocytes exposed to PCB52 or 4-OH-PCB52 over time and allows for comparison of these changes between the parent compound and its hydroxy metabolite. The datasets will allow others to explore how PCB52 and 4-OH-PCB52 impact biological pathways in preadipocytes. Further studies can be performed to determine how these changes might lead to disease. |
| first_indexed | 2024-03-12T15:04:46Z |
| format | Article |
| id | doaj.art-cf48fb5b7d4c4c13abaecacbbf6c34cf |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-03-12T15:04:46Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-cf48fb5b7d4c4c13abaecacbbf6c34cf2023-08-13T04:54:14ZengElsevierData in Brief2352-34092023-08-0149109415Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52)Francoise A. Gourronc0Michael S. Chimenti1Hans-Joachim Lehmler2James A. Ankrum3Aloysius J. Klingelhutz4Department of Microbiology and Immunology, University of IowaIowa Institute of Human Genetics, Bioinformatics Division, University of IowaDepartment of Occupational and Environmental Health, University of IowaRoy J. Carver Department of Biomedical Engineering, University of Iowa; Fraternal Order of Eagles Diabetes Research Center, University of IowaDepartment of Microbiology and Immunology, University of Iowa; Fraternal Order of Eagles Diabetes Research Center, University of Iowa; Corresponding author. 3-612 BSB, 51 Newton Road, Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, Tel: 319-335-7788.Polychlorinated biphenyls (PCBs) were used extensively in building materials, including those used in schools. PCBs accumulate in fat, and exposure to PCBs is associated with the development of cancer, neurodevelopmental disorders, cardiovascular disease, obesity, and diabetes. The non-dioxin-like PCB congener, PCB52 (2,2′,5,5′-tetrachlorobiphenyl), is found at one of the highest levels of any congener in school air. PCB52 is oxidized in the liver to hydroxylated forms, mainly 4-OH-PCB52 (2,2’,5,5’-tetrachlorobiphenyl-4-ol). In a previous study, we reported on RNAseq data generated from exposure of human preadipocytes to the dioxin-like PCB congener, PCB126. In this new dataset, we used identical techniques to examine alterations in gene transcript levels in human preadipocytes exposed to PCB52 or 4-OH-PCB52 over a time course. This updated set of data provides a comprehensive transcriptional profile of changes that occur in preadipocytes exposed to PCB52 or 4-OH-PCB52 over time and allows for comparison of these changes between the parent compound and its hydroxy metabolite. The datasets will allow others to explore how PCB52 and 4-OH-PCB52 impact biological pathways in preadipocytes. Further studies can be performed to determine how these changes might lead to disease.http://www.sciencedirect.com/science/article/pii/S2352340923005164Polychlorinated BiphenylsPCB52MetaboliteAdiposeRNAseqObesity |
| spellingShingle | Francoise A. Gourronc Michael S. Chimenti Hans-Joachim Lehmler James A. Ankrum Aloysius J. Klingelhutz Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52) Data in Brief Polychlorinated Biphenyls PCB52 Metabolite Adipose RNAseq Obesity |
| title | Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52) |
| title_full | Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52) |
| title_fullStr | Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52) |
| title_full_unstemmed | Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52) |
| title_short | Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52) |
| title_sort | updating dataset of transcriptomic changes that occur in human preadipocytes over a 3 day course of exposure to 3 3 4 4 5 pentachlorobiphenyl pcb126 with additional data on exposure to 2 2 5 5 tetrachlorobiphenyl pcb52 or its 4 hydroxy metabolite 4 oh pcb52 |
| topic | Polychlorinated Biphenyls PCB52 Metabolite Adipose RNAseq Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2352340923005164 |
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