Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia
Background and objectives: Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes to the oxidative stress and antioxidative defense mechanisms. This study aims to compare the effects of sevoflurane, desflu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-01-01
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| Series: | Brazilian Journal of Anesthesiology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001414000876 |
| _version_ | 1818024172934135808 |
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| author | Mesut Erbas Yavuz Demiraran Hayriye Ak Yildirim Gulbin Sezen Abdulkadir Iskender Ibrahim Karagoz Hayati Kandis |
| author_facet | Mesut Erbas Yavuz Demiraran Hayriye Ak Yildirim Gulbin Sezen Abdulkadir Iskender Ibrahim Karagoz Hayati Kandis |
| author_sort | Mesut Erbas |
| collection | DOAJ |
| description | Background and objectives: Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes to the oxidative stress and antioxidative defense mechanisms. This study aims to compare the effects of sevoflurane, desflurane and propofol infusion anesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy. Methods: 45 patients between 18 and 50 years with planned laparoscopic cholecystectomy under general anesthetic were included in the study. Patients were divided into three groups on the way to surgery: propofol (group P n: 15), sevoflurane (group S n: 15) and desflurane (group D n: 15). All groups were given hypnotic 2 mg/kg propofol IV, 1 mcg/kg fentanyl IV and 0.1 mg/kg vecuronium IV for induction. For maintenance of anesthesia group S were ventilated with 2% sevoflurane, group D cases were given 6% desflurane and group P were given propofol infusions of 12 mg/kg/h for the first 10 min, 9 mg/kg/h for the second 10 min and 6 mg/kg/h after that. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutation peroxidase, total oxidants and antioxidants. Results and conclusions: The 45 patients included in the study were 22 male and 23 female patients. The demographic characteristics of the groups were similar. In the postoperative period we observed that while sevoflurane and propofol increased antioxidants by a statistically significant level, desflurane increased the total oxidants level by a significant amount compared to levels before the operation. Resumo: Justificativa e objetivos: Desflurano e sevoflurano são usados com frequência para a manutenção da anestesia, e estudos mostraram que esses anestésicos causam alterações variadas nos mecanismos de defesa antioxidante contra o estresse oxidativo. Este estudo teve como objetivo comparar os efeitos de anestesias com perfusão de sevoflurano, desflurano e propofol sobre os sistemas oxidante/antioxidante de pacientes submetidos à colecistectomia laparoscópica. Métodos: Foram incluídos no estudo 45 pacientes entre 18 e 50 anos, agendados para colecistectomia laparoscópica sob anestesia geral foram incluídos no estudo. Os pacientes foram divididos em três grupos para receberem propofol (Grupo P, n: 15), sevoflurano (Grupo S, n: 15) e desflurano (Grupo D, n: 15). Todos os grupos receberam 2 mg/kg de propofol IV, 1 mcg/kg de fentanil IV e 0,1 mg/kg de vecurônio IV para indução. Para manutenção da anestesia, o Grupo S recebeu ventilação com sevoflurano a 2%, o Grupo D recebeu desflurano a 6% e o Grupo P recebeu propofol em perfusões de 12 mg/kg/h nos primeiros 10 min, 9 mg/kg/h nos 10 min seguintes e 6 mg/kg/h subsequentemente. Antes da indução e depois da cirurgia, amostras de sangue venoso foram colhidas para avaliar os níveis de glutationa peroxidase e o total de oxidantes e antioxidantes. Resultados e conclusões: Dos 45 pacientes incluídos no estudo, 22 eram do sexo masculino e 23 do sexo feminino. As características demográficas dos grupos eram semelhantes. No período pós-operatório, observamos que enquanto sevoflurano e propofol aumentaram os antioxidantes a um nível de significância estatística, desflurano aumentou o nível total de oxidantes em quantidade significativa, em comparação com os níveis pré-operação. Keywords: Oxidant, Antioxidant, Propofol, General anesthesia, Palavras-chave: Oxidante, Antioxidante, Propofol, Anestesia geral |
| first_indexed | 2024-12-10T03:56:00Z |
| format | Article |
| id | doaj.art-cf49a77a49184431a117dab79c7e66f2 |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-12-10T03:56:00Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-cf49a77a49184431a117dab79c7e66f22022-12-22T02:03:07ZengElsevierBrazilian Journal of Anesthesiology0104-00142015-01-016516872Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesiaMesut Erbas0Yavuz Demiraran1Hayriye Ak Yildirim2Gulbin Sezen3Abdulkadir Iskender4Ibrahim Karagoz5Hayati Kandis6Department of Anesthesiology and Reanimation, Medical Faculty, Çanakkale Onsekiz Mart University, Canakkale, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Duzce University, Duzce, Turkey; Corresponding author.Department of Biochemistry, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Duzce University, Duzce, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Duzce University, Duzce, TurkeyDepartment of Anesthesiology and Reanimation, Medical Faculty, Duzce University, Duzce, TurkeyDepartment of Emergency Medicine, Medical Faculty, Duzce University, Duzce, TurkeyBackground and objectives: Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes to the oxidative stress and antioxidative defense mechanisms. This study aims to compare the effects of sevoflurane, desflurane and propofol infusion anesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy. Methods: 45 patients between 18 and 50 years with planned laparoscopic cholecystectomy under general anesthetic were included in the study. Patients were divided into three groups on the way to surgery: propofol (group P n: 15), sevoflurane (group S n: 15) and desflurane (group D n: 15). All groups were given hypnotic 2 mg/kg propofol IV, 1 mcg/kg fentanyl IV and 0.1 mg/kg vecuronium IV for induction. For maintenance of anesthesia group S were ventilated with 2% sevoflurane, group D cases were given 6% desflurane and group P were given propofol infusions of 12 mg/kg/h for the first 10 min, 9 mg/kg/h for the second 10 min and 6 mg/kg/h after that. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutation peroxidase, total oxidants and antioxidants. Results and conclusions: The 45 patients included in the study were 22 male and 23 female patients. The demographic characteristics of the groups were similar. In the postoperative period we observed that while sevoflurane and propofol increased antioxidants by a statistically significant level, desflurane increased the total oxidants level by a significant amount compared to levels before the operation. Resumo: Justificativa e objetivos: Desflurano e sevoflurano são usados com frequência para a manutenção da anestesia, e estudos mostraram que esses anestésicos causam alterações variadas nos mecanismos de defesa antioxidante contra o estresse oxidativo. Este estudo teve como objetivo comparar os efeitos de anestesias com perfusão de sevoflurano, desflurano e propofol sobre os sistemas oxidante/antioxidante de pacientes submetidos à colecistectomia laparoscópica. Métodos: Foram incluídos no estudo 45 pacientes entre 18 e 50 anos, agendados para colecistectomia laparoscópica sob anestesia geral foram incluídos no estudo. Os pacientes foram divididos em três grupos para receberem propofol (Grupo P, n: 15), sevoflurano (Grupo S, n: 15) e desflurano (Grupo D, n: 15). Todos os grupos receberam 2 mg/kg de propofol IV, 1 mcg/kg de fentanil IV e 0,1 mg/kg de vecurônio IV para indução. Para manutenção da anestesia, o Grupo S recebeu ventilação com sevoflurano a 2%, o Grupo D recebeu desflurano a 6% e o Grupo P recebeu propofol em perfusões de 12 mg/kg/h nos primeiros 10 min, 9 mg/kg/h nos 10 min seguintes e 6 mg/kg/h subsequentemente. Antes da indução e depois da cirurgia, amostras de sangue venoso foram colhidas para avaliar os níveis de glutationa peroxidase e o total de oxidantes e antioxidantes. Resultados e conclusões: Dos 45 pacientes incluídos no estudo, 22 eram do sexo masculino e 23 do sexo feminino. As características demográficas dos grupos eram semelhantes. No período pós-operatório, observamos que enquanto sevoflurano e propofol aumentaram os antioxidantes a um nível de significância estatística, desflurano aumentou o nível total de oxidantes em quantidade significativa, em comparação com os níveis pré-operação. Keywords: Oxidant, Antioxidant, Propofol, General anesthesia, Palavras-chave: Oxidante, Antioxidante, Propofol, Anestesia geralhttp://www.sciencedirect.com/science/article/pii/S0104001414000876 |
| spellingShingle | Mesut Erbas Yavuz Demiraran Hayriye Ak Yildirim Gulbin Sezen Abdulkadir Iskender Ibrahim Karagoz Hayati Kandis Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia Brazilian Journal of Anesthesiology |
| title | Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia |
| title_full | Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia |
| title_fullStr | Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia |
| title_full_unstemmed | Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia |
| title_short | Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia |
| title_sort | comparison of effects on the oxidant antioxidant system of sevoflurane desflurane and propofol infusion during general anesthesia |
| url | http://www.sciencedirect.com/science/article/pii/S0104001414000876 |
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