To what extent is blood a reasonable surrogate for brain in gene expression studies: estimation from mouse hippocampus and spleen
Microarrays are designed to measure genome-wide differences in gene expression. In cases where a tissue is not accessible for analysis (e.g. human brain), it is of interest to determine whether a second, accessible tissue could be used as a surrogate for transcription profiling. Surrogacy has applic...
Main Authors: | Matthew N Davies, Sarah Lawn, Steven Whatley, Cathy Fernandes, Robert W Williams, Leonard C Schalkwyk |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2009-10-01
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Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.15.002.2009/full |
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