The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis
The first line of defense in innate immunity is provided by cellular and humoral mediators. Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate immunity. PTX3, the first long pentraxin identified, is a soluble pattern recognition molecule rapidly produced by severa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00794/full |
| _version_ | 1818145147278327808 |
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| author | Rémi Porte Sadaf Davoudian Fatemeh Asgari Raffaella Parente Alberto Mantovani Alberto Mantovani Alberto Mantovani Cecilia Garlanda Cecilia Garlanda Barbara Bottazzi |
| author_facet | Rémi Porte Sadaf Davoudian Fatemeh Asgari Raffaella Parente Alberto Mantovani Alberto Mantovani Alberto Mantovani Cecilia Garlanda Cecilia Garlanda Barbara Bottazzi |
| author_sort | Rémi Porte |
| collection | DOAJ |
| description | The first line of defense in innate immunity is provided by cellular and humoral mediators. Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate immunity. PTX3, the first long pentraxin identified, is a soluble pattern recognition molecule rapidly produced by several cell types in response to primary pro-inflammatory signals and microbial recognition. PTX3 acts as an important mediator of innate immunity against pathogens of fungal, bacterial and viral origin, and as a regulator of inflammation, by modulating complement activation and cell extravasation, and facilitating pathogen recognition by myeloid cells. In sepsis, PTX3 plasma levels are associated with severity of the condition, patient survival, and response to therapy. In combination with other established biomarkers, PTX3 could improve stratification of sepsis patients and thus, complement the system of classification and monitoring of this disease. |
| first_indexed | 2024-12-11T11:58:50Z |
| format | Article |
| id | doaj.art-cf52847d623c4fd0a2a2817cd437916e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T11:58:50Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cf52847d623c4fd0a2a2817cd437916e2022-12-22T01:08:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00794445874The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and SepsisRémi Porte0Sadaf Davoudian1Fatemeh Asgari2Raffaella Parente3Alberto Mantovani4Alberto Mantovani5Alberto Mantovani6Cecilia Garlanda7Cecilia Garlanda8Barbara Bottazzi9Department of Inflammation and Immunology, Humanitas Clinical and Research Center-IRCCS, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyDepartment of Inflammation and Immunology, Humanitas Clinical and Research Center-IRCCS, Milan, ItalyDepartment of Inflammation and Immunology, Humanitas Clinical and Research Center-IRCCS, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyThe William Harvey Research Institute, Queen Mary University of London, London, United KingdomDepartment of Inflammation and Immunology, Humanitas Clinical and Research Center-IRCCS, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyDepartment of Inflammation and Immunology, Humanitas Clinical and Research Center-IRCCS, Milan, ItalyThe first line of defense in innate immunity is provided by cellular and humoral mediators. Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate immunity. PTX3, the first long pentraxin identified, is a soluble pattern recognition molecule rapidly produced by several cell types in response to primary pro-inflammatory signals and microbial recognition. PTX3 acts as an important mediator of innate immunity against pathogens of fungal, bacterial and viral origin, and as a regulator of inflammation, by modulating complement activation and cell extravasation, and facilitating pathogen recognition by myeloid cells. In sepsis, PTX3 plasma levels are associated with severity of the condition, patient survival, and response to therapy. In combination with other established biomarkers, PTX3 could improve stratification of sepsis patients and thus, complement the system of classification and monitoring of this disease.https://www.frontiersin.org/article/10.3389/fimmu.2019.00794/fullpentraxinpentraxin 3 (PTX3)inflammationinnate immunitysepsis |
| spellingShingle | Rémi Porte Sadaf Davoudian Fatemeh Asgari Raffaella Parente Alberto Mantovani Alberto Mantovani Alberto Mantovani Cecilia Garlanda Cecilia Garlanda Barbara Bottazzi The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis Frontiers in Immunology pentraxin pentraxin 3 (PTX3) inflammation innate immunity sepsis |
| title | The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis |
| title_full | The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis |
| title_fullStr | The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis |
| title_full_unstemmed | The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis |
| title_short | The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis |
| title_sort | long pentraxin ptx3 as a humoral innate immunity functional player and biomarker of infections and sepsis |
| topic | pentraxin pentraxin 3 (PTX3) inflammation innate immunity sepsis |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00794/full |
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