IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice

IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice

Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of insulin-producing β cells. BDC2.5 T cells in BDC2.5 CD4+ T cell receptor transgenic Non-Obese Diabetic (NOD) mice (BDC2.5+ NOD mice) can abruptly invade the pancreatic islets resulting in severe insulitis that progress...

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Bibliographic Details
Main Authors: Juan Huang, Qiyuan Tan, Ningwen Tai, James Alexander Pearson, Yangyang Li, Chen Chao, Lucy Zhang, Jian Peng, Yanpeng Xing, Luyao Zhang, Youjia Hu, Zhiguang Zhou, F. Susan Wong, Li Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
interleukin-10
neutrophils
gut microbiota
CD4+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702955/full

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