Induction of Myocardial Infarction in Experimental Animals: A Review
Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is diffi...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2018-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/12221/36997_CE[Ra]_F(P)_PF1(SJ_SHU)_PN(SHU).pdf |
| _version_ | 1818403240964784128 |
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| author | Syarifah Aisyah Syed Abd Halim Norzana Abd Ghafar Zakiah Jubri Srijit Das |
| author_facet | Syarifah Aisyah Syed Abd Halim Norzana Abd Ghafar Zakiah Jubri Srijit Das |
| author_sort | Syarifah Aisyah Syed Abd Halim |
| collection | DOAJ |
| description | Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is difficult to create necrosis similar to those found in human heart, various large and small animals were used to create experimental model of MI. Each of these animals and method of selection offers various advantages and disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MI in experimental animals. These methods may be beneficial for academicians and researchers concerned with the treatment of MI. |
| first_indexed | 2024-12-14T08:21:07Z |
| format | Article |
| id | doaj.art-cf54109d4b2546778c0c7624c676dbb2 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T08:21:07Z |
| publishDate | 2018-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-cf54109d4b2546778c0c7624c676dbb22022-12-21T23:09:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-11-011211AE01AE0510.7860/JCDR/2018/36997.12221Induction of Myocardial Infarction in Experimental Animals: A ReviewSyarifah Aisyah Syed Abd Halim0Norzana Abd Ghafar1Zakiah Jubri2Srijit Das3Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.Professor, Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.Associate Professor, Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.Professor, Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is difficult to create necrosis similar to those found in human heart, various large and small animals were used to create experimental model of MI. Each of these animals and method of selection offers various advantages and disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MI in experimental animals. These methods may be beneficial for academicians and researchers concerned with the treatment of MI.https://jcdr.net/articles/PDF/12221/36997_CE[Ra]_F(P)_PF1(SJ_SHU)_PN(SHU).pdfcoronary arteryisoprenalineligationmyocardial infarction |
| spellingShingle | Syarifah Aisyah Syed Abd Halim Norzana Abd Ghafar Zakiah Jubri Srijit Das Induction of Myocardial Infarction in Experimental Animals: A Review Journal of Clinical and Diagnostic Research coronary artery isoprenaline ligation myocardial infarction |
| title | Induction of Myocardial Infarction in Experimental Animals: A Review |
| title_full | Induction of Myocardial Infarction in Experimental Animals: A Review |
| title_fullStr | Induction of Myocardial Infarction in Experimental Animals: A Review |
| title_full_unstemmed | Induction of Myocardial Infarction in Experimental Animals: A Review |
| title_short | Induction of Myocardial Infarction in Experimental Animals: A Review |
| title_sort | induction of myocardial infarction in experimental animals a review |
| topic | coronary artery isoprenaline ligation myocardial infarction |
| url | https://jcdr.net/articles/PDF/12221/36997_CE[Ra]_F(P)_PF1(SJ_SHU)_PN(SHU).pdf |
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