No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness
Background Adverse childhood experiences (ACEs) have been linked to increased cardiovascular disease (CVD) risk. Previous reports have suggested that accelerated biological aging—indexed by telomere length (TL) and mitochondrial DNA copy number (mtDNAcn)—may contribute to associations between ACEs a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.026619 |
| _version_ | 1811170064635789312 |
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| author | Nathaniel J. Iannarelli Terrance J. Wade Kylie S. Dempster Jessy Moore Adam J. MacNeil Deborah D. O'Leary |
| author_facet | Nathaniel J. Iannarelli Terrance J. Wade Kylie S. Dempster Jessy Moore Adam J. MacNeil Deborah D. O'Leary |
| author_sort | Nathaniel J. Iannarelli |
| collection | DOAJ |
| description | Background Adverse childhood experiences (ACEs) have been linked to increased cardiovascular disease (CVD) risk. Previous reports have suggested that accelerated biological aging—indexed by telomere length (TL) and mitochondrial DNA copy number (mtDNAcn)—may contribute to associations between ACEs and cardiovascular health outcomes. Here, we examine the potential mediating effects of TL and mtDNAcn on the association between ACEs and central arterial stiffness—an intermediate cardiovascular health outcome—as a novel pathway linking ACEs to CVD risk among young adults. Methods and Results One hundred and eighty‐five (n=102 women; mean age, 22.5±1.5 years) individuals provided information on ACEs. TL (kb per diploid cell) and mtDNAcn (copies per diploid cell) were quantified using quantitative polymerase chain reaction techniques. Central arterial stiffness was measured as carotid‐femoral pulse wave velocity (cfPWV; m/s). Multiple linear regression analyses were used to examine the associations between ACEs, TL, mtDNAcn, and cfPWV. ACEs were positively associated with cfPWV (β=0.147, P=0.035). TL (β=−0.170, P=0.011) and mtDNAcn (β=−0.159, P=0.019) were inversely associated with cfPWV. Neither TL (β=−0.027, P=0.726) nor mtDNAcn (β=0.038, P=0.620) was associated with ACEs. Neither marker mediated the association between ACEs and cfPWV. Conclusions An increasing number of ACEs were associated with a faster cfPWV and thus, a greater degree of central arterial stiffness. ACEs were not associated with either TL or mtDNAcn, suggesting that these markers do not represent a mediating pathway linking ACEs to central arterial stiffness. |
| first_indexed | 2024-04-10T16:52:26Z |
| format | Article |
| id | doaj.art-cf54d53053f44890a80f4fdaca1a1a97 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T16:52:26Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-cf54d53053f44890a80f4fdaca1a1a972023-02-07T16:02:54ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-11-01112110.1161/JAHA.122.026619No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial StiffnessNathaniel J. Iannarelli0Terrance J. Wade1Kylie S. Dempster2Jessy Moore3Adam J. MacNeil4Deborah D. O'Leary5Department of Health Sciences Faculty of Applied Health Sciences Brock University St. Catharines Ontario CanadaDepartment of Health Sciences Faculty of Applied Health Sciences Brock University St. Catharines Ontario CanadaDepartment of Health Sciences Faculty of Applied Health Sciences Brock University St. Catharines Ontario CanadaDepartment of Health Sciences Faculty of Applied Health Sciences Brock University St. Catharines Ontario CanadaDepartment of Health Sciences Faculty of Applied Health Sciences Brock University St. Catharines Ontario CanadaDepartment of Health Sciences Faculty of Applied Health Sciences Brock University St. Catharines Ontario CanadaBackground Adverse childhood experiences (ACEs) have been linked to increased cardiovascular disease (CVD) risk. Previous reports have suggested that accelerated biological aging—indexed by telomere length (TL) and mitochondrial DNA copy number (mtDNAcn)—may contribute to associations between ACEs and cardiovascular health outcomes. Here, we examine the potential mediating effects of TL and mtDNAcn on the association between ACEs and central arterial stiffness—an intermediate cardiovascular health outcome—as a novel pathway linking ACEs to CVD risk among young adults. Methods and Results One hundred and eighty‐five (n=102 women; mean age, 22.5±1.5 years) individuals provided information on ACEs. TL (kb per diploid cell) and mtDNAcn (copies per diploid cell) were quantified using quantitative polymerase chain reaction techniques. Central arterial stiffness was measured as carotid‐femoral pulse wave velocity (cfPWV; m/s). Multiple linear regression analyses were used to examine the associations between ACEs, TL, mtDNAcn, and cfPWV. ACEs were positively associated with cfPWV (β=0.147, P=0.035). TL (β=−0.170, P=0.011) and mtDNAcn (β=−0.159, P=0.019) were inversely associated with cfPWV. Neither TL (β=−0.027, P=0.726) nor mtDNAcn (β=0.038, P=0.620) was associated with ACEs. Neither marker mediated the association between ACEs and cfPWV. Conclusions An increasing number of ACEs were associated with a faster cfPWV and thus, a greater degree of central arterial stiffness. ACEs were not associated with either TL or mtDNAcn, suggesting that these markers do not represent a mediating pathway linking ACEs to central arterial stiffness.https://www.ahajournals.org/doi/10.1161/JAHA.122.026619adverse childhood experiencesbiological agingcentral arterial stiffnessmitochondrial DNA copy numbertelomere lengthvascular aging |
| spellingShingle | Nathaniel J. Iannarelli Terrance J. Wade Kylie S. Dempster Jessy Moore Adam J. MacNeil Deborah D. O'Leary No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease adverse childhood experiences biological aging central arterial stiffness mitochondrial DNA copy number telomere length vascular aging |
| title | No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness |
| title_full | No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness |
| title_fullStr | No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness |
| title_full_unstemmed | No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness |
| title_short | No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness |
| title_sort | no mediation effect of telomere length or mitochondrial dna copy number on the association between adverse childhood experiences aces and central arterial stiffness |
| topic | adverse childhood experiences biological aging central arterial stiffness mitochondrial DNA copy number telomere length vascular aging |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.026619 |
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