The Roles of Periodontal Bacteria in Atherosclerosis
Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susce...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/12861 |
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| author | Xiaofei Huang Mengru Xie Xiaofeng Lu Feng Mei Wencheng Song Yang Liu Lili Chen |
| author_facet | Xiaofei Huang Mengru Xie Xiaofeng Lu Feng Mei Wencheng Song Yang Liu Lili Chen |
| author_sort | Xiaofei Huang |
| collection | DOAJ |
| description | Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including <i>Porphyromonas gingivalis</i>, <i>Aggregatibacter actinomycetemcomitans</i>, and <i>Fusobacterium nucleatum</i>. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS. |
| first_indexed | 2024-03-10T23:52:46Z |
| format | Article |
| id | doaj.art-cf55228c91a04869be2b91422419bca4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:52:46Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cf55228c91a04869be2b91422419bca42023-11-19T01:31:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161286110.3390/ijms241612861The Roles of Periodontal Bacteria in AtherosclerosisXiaofei Huang0Mengru Xie1Xiaofeng Lu2Feng Mei3Wencheng Song4Yang Liu5Lili Chen6Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaAtherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including <i>Porphyromonas gingivalis</i>, <i>Aggregatibacter actinomycetemcomitans</i>, and <i>Fusobacterium nucleatum</i>. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS.https://www.mdpi.com/1422-0067/24/16/12861atherosclerosisCVDperiodontal pathogens<i>Porphyromonas gingivalis</i><i>Aggregatibacter actinomycetemcomitans</i><i>Fusobacterium nucleatum</i> |
| spellingShingle | Xiaofei Huang Mengru Xie Xiaofeng Lu Feng Mei Wencheng Song Yang Liu Lili Chen The Roles of Periodontal Bacteria in Atherosclerosis International Journal of Molecular Sciences atherosclerosis CVD periodontal pathogens <i>Porphyromonas gingivalis</i> <i>Aggregatibacter actinomycetemcomitans</i> <i>Fusobacterium nucleatum</i> |
| title | The Roles of Periodontal Bacteria in Atherosclerosis |
| title_full | The Roles of Periodontal Bacteria in Atherosclerosis |
| title_fullStr | The Roles of Periodontal Bacteria in Atherosclerosis |
| title_full_unstemmed | The Roles of Periodontal Bacteria in Atherosclerosis |
| title_short | The Roles of Periodontal Bacteria in Atherosclerosis |
| title_sort | roles of periodontal bacteria in atherosclerosis |
| topic | atherosclerosis CVD periodontal pathogens <i>Porphyromonas gingivalis</i> <i>Aggregatibacter actinomycetemcomitans</i> <i>Fusobacterium nucleatum</i> |
| url | https://www.mdpi.com/1422-0067/24/16/12861 |
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