Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.

Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.

Ischaemic stroke is caused by occlusive thrombi in the cerebral vasculature. Although tissue-plasminogen activator (tPA) can be administered as thrombolytic therapy, it has major limitations, which include disruption of the blood-brain barrier and an increased risk of bleeding. Treatments that preve...

书目详细资料
Main Authors:	Anna P Andreou, Maria Efthymiou, Yao Yu, Helena R Watts, Faruq H Noormohamed, Daqing Ma, David A Lane, James T B Crawley
格式:	文件
语言:	English
出版:	Public Library of Science (PLoS) 2015-01-01
丛编:	PLoS ONE
在线阅读:	http://europepmc.org/articles/PMC4382112?pdf=render

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