Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia.
We conducted a large retrospective study to investigate the confounding factors that predict Ce ROC under propofol-based TIVA with TCI. We recorded sex, age, height, weight, Ce LOC, Ce ROC, total propofol and fentanyl consumption dose, and anesthetic time. Simple linear regression models were used t...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4418734?pdf=render |
| _version_ | 1818552843103109120 |
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| author | Shun-Ming Chan Meei-Shyuan Lee Chueng-He Lu Chen-Hwan Cherng Yuan-Shiou Huang Chun-Chang Yeh Chan-Yang Kuo Zhi-Fu Wu |
| author_facet | Shun-Ming Chan Meei-Shyuan Lee Chueng-He Lu Chen-Hwan Cherng Yuan-Shiou Huang Chun-Chang Yeh Chan-Yang Kuo Zhi-Fu Wu |
| author_sort | Shun-Ming Chan |
| collection | DOAJ |
| description | We conducted a large retrospective study to investigate the confounding factors that predict Ce ROC under propofol-based TIVA with TCI. We recorded sex, age, height, weight, Ce LOC, Ce ROC, total propofol and fentanyl consumption dose, and anesthetic time. Simple linear regression models were used to identify potential predictors of Ce ROC, and multiple linear regression models were used to identify the confounding predictors of Ce ROC. We found that Ce ROC correlated with age, sex, Ce LOC, and both total fentanyl and propofol consumption dose. The prediction formula was: Ce ROC = 0.87 - 0.06 × age + 0.18 × Ce LOC + 0.04 (if fentanyl consumption > 150 μg; if not, ignore this value) + 0.07 × (1 or 2, according to the total propofol consumption dose, 1 for a propofol amount 1000-2000 mg and 2 for a propofol amount > 2000 mg). We simplified the formula further as Ce ROC = 0.87 - 0.06 × age + 0.18 × Ce LOC. In conclusion, Ce ROC can be predicted under TCI with propofol- and fentanyl-based TIVA. The confounding factors that predicted propofol Ce ROC are age, sex, Ce LOC, and total consumption dose of propofol and fentanyl. |
| first_indexed | 2024-12-12T09:18:23Z |
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| id | doaj.art-cf56c33bcd254b0a90a19f5083cb03a0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T09:18:23Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-cf56c33bcd254b0a90a19f5083cb03a02022-12-22T00:29:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012434310.1371/journal.pone.0124343Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia.Shun-Ming ChanMeei-Shyuan LeeChueng-He LuChen-Hwan CherngYuan-Shiou HuangChun-Chang YehChan-Yang KuoZhi-Fu WuWe conducted a large retrospective study to investigate the confounding factors that predict Ce ROC under propofol-based TIVA with TCI. We recorded sex, age, height, weight, Ce LOC, Ce ROC, total propofol and fentanyl consumption dose, and anesthetic time. Simple linear regression models were used to identify potential predictors of Ce ROC, and multiple linear regression models were used to identify the confounding predictors of Ce ROC. We found that Ce ROC correlated with age, sex, Ce LOC, and both total fentanyl and propofol consumption dose. The prediction formula was: Ce ROC = 0.87 - 0.06 × age + 0.18 × Ce LOC + 0.04 (if fentanyl consumption > 150 μg; if not, ignore this value) + 0.07 × (1 or 2, according to the total propofol consumption dose, 1 for a propofol amount 1000-2000 mg and 2 for a propofol amount > 2000 mg). We simplified the formula further as Ce ROC = 0.87 - 0.06 × age + 0.18 × Ce LOC. In conclusion, Ce ROC can be predicted under TCI with propofol- and fentanyl-based TIVA. The confounding factors that predicted propofol Ce ROC are age, sex, Ce LOC, and total consumption dose of propofol and fentanyl.http://europepmc.org/articles/PMC4418734?pdf=render |
| spellingShingle | Shun-Ming Chan Meei-Shyuan Lee Chueng-He Lu Chen-Hwan Cherng Yuan-Shiou Huang Chun-Chang Yeh Chan-Yang Kuo Zhi-Fu Wu Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia. PLoS ONE |
| title | Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia. |
| title_full | Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia. |
| title_fullStr | Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia. |
| title_full_unstemmed | Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia. |
| title_short | Confounding factors to predict the awakening effect-site concentration of propofol in target-controlled infusion based on propofol and fentanyl anesthesia. |
| title_sort | confounding factors to predict the awakening effect site concentration of propofol in target controlled infusion based on propofol and fentanyl anesthesia |
| url | http://europepmc.org/articles/PMC4418734?pdf=render |
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