Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation
While probiotics are reported to reduce the risks of neonatal morbidities, less is known about probiotics and feeding tolerance. With this retrospective cohort study, we investigate whether introduction of probiotic supplementation as the standard of care was associated with fewer neonatal morbiditi...
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3646 |
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| author | Ayoub Mitha Sofia Söderquist Kruth Sara Bjurman Alexander Rakow Stefan Johansson |
| author_facet | Ayoub Mitha Sofia Söderquist Kruth Sara Bjurman Alexander Rakow Stefan Johansson |
| author_sort | Ayoub Mitha |
| collection | DOAJ |
| description | While probiotics are reported to reduce the risks of neonatal morbidities, less is known about probiotics and feeding tolerance. With this retrospective cohort study, we investigate whether introduction of probiotic supplementation as the standard of care was associated with fewer neonatal morbidities and improved feeding tolerance in very preterm infants. Using the Swedish Neonatal Quality Register, 345 live-born very preterm infants (28–31 weeks’ gestation), from January 2019–August 2021, in NICUs in Stockholm, Sweden, either received probiotic supplementation (<i>Bifidobacterium infantis</i>, <i>Bifidobacterium lactis</i>, <i>Streptococcus</i><i>thermophilus</i>) (139) or no supplementation (206); they were compared regarding a primary composite outcome of death, sepsis, and/or necrotising enterocolitis and secondary outcomes: time to full enteral feeding and antibiotics use. Probiotics seemed associated with a reduced risk of the composite outcome (4.3% versus 9.2%, <i>p</i> = 0.08). In the subgroup of 320 infants without the primary outcome, probiotics were associated with shorter time to full enteral feeding (6.6 days versus 7.2 days) and less use of antibiotics (5.2 days versus 6.1 days). Our findings suggest that probiotics improve feeding tolerance and further support that very preterm infants may benefit from probiotic supplementation. |
| first_indexed | 2024-03-10T01:24:17Z |
| format | Article |
| id | doaj.art-cf57700c79454e7687f289103af37693 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:24:17Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-cf57700c79454e7687f289103af376932023-11-23T13:53:59ZengMDPI AGNutrients2072-66432022-09-011417364610.3390/nu14173646Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic SupplementationAyoub Mitha0Sofia Söderquist Kruth1Sara Bjurman2Alexander Rakow3Stefan Johansson4Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, 17177 Stockholm, SwedenWomen’s Health and Allied Health Professional Theme, Karolinska University Hospital, Solna, 17176 Stockholm, SwedenSachs Children and Youth Hospital, Södersjukhuset, 11883 Stockholm, SwedenDepartment of Women’s and Children’s Health, Karolinska Institutet, 17177 Stockholm, SwedenDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, 17177 Stockholm, SwedenWhile probiotics are reported to reduce the risks of neonatal morbidities, less is known about probiotics and feeding tolerance. With this retrospective cohort study, we investigate whether introduction of probiotic supplementation as the standard of care was associated with fewer neonatal morbidities and improved feeding tolerance in very preterm infants. Using the Swedish Neonatal Quality Register, 345 live-born very preterm infants (28–31 weeks’ gestation), from January 2019–August 2021, in NICUs in Stockholm, Sweden, either received probiotic supplementation (<i>Bifidobacterium infantis</i>, <i>Bifidobacterium lactis</i>, <i>Streptococcus</i><i>thermophilus</i>) (139) or no supplementation (206); they were compared regarding a primary composite outcome of death, sepsis, and/or necrotising enterocolitis and secondary outcomes: time to full enteral feeding and antibiotics use. Probiotics seemed associated with a reduced risk of the composite outcome (4.3% versus 9.2%, <i>p</i> = 0.08). In the subgroup of 320 infants without the primary outcome, probiotics were associated with shorter time to full enteral feeding (6.6 days versus 7.2 days) and less use of antibiotics (5.2 days versus 6.1 days). Our findings suggest that probiotics improve feeding tolerance and further support that very preterm infants may benefit from probiotic supplementation.https://www.mdpi.com/2072-6643/14/17/3646probiotic supplementationvery preterm infantsfeeding toleranceneonatal morbiditiesnecrotising enterocolitisfull enteral feeding |
| spellingShingle | Ayoub Mitha Sofia Söderquist Kruth Sara Bjurman Alexander Rakow Stefan Johansson Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation Nutrients probiotic supplementation very preterm infants feeding tolerance neonatal morbidities necrotising enterocolitis full enteral feeding |
| title | Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation |
| title_full | Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation |
| title_fullStr | Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation |
| title_full_unstemmed | Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation |
| title_short | Neonatal Morbidities and Feeding Tolerance Outcomes in Very Preterm Infants, before and after Introduction of Probiotic Supplementation |
| title_sort | neonatal morbidities and feeding tolerance outcomes in very preterm infants before and after introduction of probiotic supplementation |
| topic | probiotic supplementation very preterm infants feeding tolerance neonatal morbidities necrotising enterocolitis full enteral feeding |
| url | https://www.mdpi.com/2072-6643/14/17/3646 |
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