Myeloid-derived suppressor cells in bacterial infections

Myeloid-derived suppressor cells in bacterial infections

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious dise...

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Bibliographic Details
Main Authors: Michael eOst, Anurag eSingh, Andreas ePeschel, Roman eMehling, Nikolaus eRieber, Dominik eHartl
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Bacteria
Infection
Sepsis
immune suppression
myeloid-derived suppressor cells
MDSC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00037/full
Description
Summary:Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.
ISSN:2235-2988

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