Myeloid-derived suppressor cells in bacterial infections
Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious dise...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00037/full |
| _version_ | 1818081642562977792 |
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| author | Michael eOst Anurag eSingh Andreas ePeschel Roman eMehling Nikolaus eRieber Nikolaus eRieber Dominik eHartl |
| author_facet | Michael eOst Anurag eSingh Andreas ePeschel Roman eMehling Nikolaus eRieber Nikolaus eRieber Dominik eHartl |
| author_sort | Michael eOst |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics. |
| first_indexed | 2024-12-10T19:09:27Z |
| format | Article |
| id | doaj.art-cf5848ed611c4445af8d81ed4f48e10f |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-10T19:09:27Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-cf5848ed611c4445af8d81ed4f48e10f2022-12-22T01:36:48ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882016-03-01610.3389/fcimb.2016.00037183538Myeloid-derived suppressor cells in bacterial infectionsMichael eOst0Anurag eSingh1Andreas ePeschel2Roman eMehling3Nikolaus eRieber4Nikolaus eRieber5Dominik eHartl6University of TübingenUniversity of TübingenInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology Dept., University of Tübingen, Tübingen, GermanyUniversity of TübingenUniversity of TübingenDepartment of Pediatrics, Kinderklinik München Schwabing, Klinikum Schwabing, StKM GmbH und Klinikum rechts der Isar, Technische Universität München, Munich, GermanyUniversity of TübingenMyeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00037/fullBacteriaInfectionSepsisimmune suppressionmyeloid-derived suppressor cellsMDSC |
| spellingShingle | Michael eOst Anurag eSingh Andreas ePeschel Roman eMehling Nikolaus eRieber Nikolaus eRieber Dominik eHartl Myeloid-derived suppressor cells in bacterial infections Frontiers in Cellular and Infection Microbiology Bacteria Infection Sepsis immune suppression myeloid-derived suppressor cells MDSC |
| title | Myeloid-derived suppressor cells in bacterial infections |
| title_full | Myeloid-derived suppressor cells in bacterial infections |
| title_fullStr | Myeloid-derived suppressor cells in bacterial infections |
| title_full_unstemmed | Myeloid-derived suppressor cells in bacterial infections |
| title_short | Myeloid-derived suppressor cells in bacterial infections |
| title_sort | myeloid derived suppressor cells in bacterial infections |
| topic | Bacteria Infection Sepsis immune suppression myeloid-derived suppressor cells MDSC |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00037/full |
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