Co-orientation of replication and transcription preserves genome integrity.
In many bacteria, there is a genome-wide bias towards co-orientation of replication and transcription, with essential and/or highly-expressed genes further enriched co-directionally. We previously found that reversing this bias in the bacterium Bacillus subtilis slows replication elongation, and we...
Main Authors: | Anjana Srivatsan, Ashley Tehranchi, David M MacAlpine, Jue D Wang |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-01-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2797598?pdf=render |
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