Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke
This study evaluated whether osteoporosis pharmacotherapy (OPT) affected functional outcomes in acute ischemic stroke patients with osteoporosis. Using a single-center registry database, we consecutively registered acute ischemic stroke patients between May 2016 and December 2020. All patients older...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/15/4905 |
| _version_ | 1797586553718964224 |
|---|---|
| author | Jong-Hee Sohn Chulho Kim Yerim Kim So Young Park Sang-Hwa Lee |
| author_facet | Jong-Hee Sohn Chulho Kim Yerim Kim So Young Park Sang-Hwa Lee |
| author_sort | Jong-Hee Sohn |
| collection | DOAJ |
| description | This study evaluated whether osteoporosis pharmacotherapy (OPT) affected functional outcomes in acute ischemic stroke patients with osteoporosis. Using a single-center registry database, we consecutively registered acute ischemic stroke patients between May 2016 and December 2020. All patients older than 55 years underwent routine bone densitometry within 7 days of stroke onset. OPT prescription was confirmed by reviewing medical records. We classified the patients into OPT and no OPT groups. We performed propensity score matching (PSM) to overcome the imbalance in multiple covariates between the two groups. We investigated whether OPT affected 1-year functional outcomes by multivariate analysis using a PSM cohort. Among 1307 consecutively registered acute ischemic stroke patients, 381 patients were enrolled in this study, of whom 134 (35.2%) were prescribed OPT at discharge, which was maintained for 1 year. In a multivariate analysis using a PSM cohort, the OPT group had a lower risk of dependency (odds ratio [OR], 0.52; 95% confidence interval [CI], 0.27–0.996) and poor functional outcome at 1 year (OR, 0.24; 95% CI, 0.10–0.57). The OPT group also had increased chance of late functional improvement (OR, 6.16; 95% CI, 1.12–33.79). This study showed that OPT could reduce dependency and poor functional outcomes and increase the chance of improving functional outcomes at 3 months and 1 year after ischemic stroke onset, and these findings could be helpful for improving functional outcomes and bone health after ischemic stroke. |
| first_indexed | 2024-03-11T00:24:48Z |
| format | Article |
| id | doaj.art-cf58b4fe2bd143569c70ad9333b6cd26 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:48Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cf58b4fe2bd143569c70ad9333b6cd262023-11-18T23:06:47ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215490510.3390/jcm12154905Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic StrokeJong-Hee Sohn0Chulho Kim1Yerim Kim2So Young Park3Sang-Hwa Lee4Department of Neurology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 24252, Republic of KoreaDepartment of Neurology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 24252, Republic of KoreaDepartment of Neurology, Kangdong Sacred Heart Hospital, Seoul 07441, Republic of KoreaDepartment of Endocrinology and Metabolism, Kyung Hee University Hospital, Seoul 05278, Republic of KoreaDepartment of Neurology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 24252, Republic of KoreaThis study evaluated whether osteoporosis pharmacotherapy (OPT) affected functional outcomes in acute ischemic stroke patients with osteoporosis. Using a single-center registry database, we consecutively registered acute ischemic stroke patients between May 2016 and December 2020. All patients older than 55 years underwent routine bone densitometry within 7 days of stroke onset. OPT prescription was confirmed by reviewing medical records. We classified the patients into OPT and no OPT groups. We performed propensity score matching (PSM) to overcome the imbalance in multiple covariates between the two groups. We investigated whether OPT affected 1-year functional outcomes by multivariate analysis using a PSM cohort. Among 1307 consecutively registered acute ischemic stroke patients, 381 patients were enrolled in this study, of whom 134 (35.2%) were prescribed OPT at discharge, which was maintained for 1 year. In a multivariate analysis using a PSM cohort, the OPT group had a lower risk of dependency (odds ratio [OR], 0.52; 95% confidence interval [CI], 0.27–0.996) and poor functional outcome at 1 year (OR, 0.24; 95% CI, 0.10–0.57). The OPT group also had increased chance of late functional improvement (OR, 6.16; 95% CI, 1.12–33.79). This study showed that OPT could reduce dependency and poor functional outcomes and increase the chance of improving functional outcomes at 3 months and 1 year after ischemic stroke onset, and these findings could be helpful for improving functional outcomes and bone health after ischemic stroke.https://www.mdpi.com/2077-0383/12/15/4905osteoporosisosteoporosis pharmacotherapybisphosphonatefunctional outcomesischemic stroke |
| spellingShingle | Jong-Hee Sohn Chulho Kim Yerim Kim So Young Park Sang-Hwa Lee Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke Journal of Clinical Medicine osteoporosis osteoporosis pharmacotherapy bisphosphonate functional outcomes ischemic stroke |
| title | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
| title_full | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
| title_fullStr | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
| title_full_unstemmed | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
| title_short | Impact of Osteoporosis Pharmacotherapy on Functional Outcomes after Ischemic Stroke |
| title_sort | impact of osteoporosis pharmacotherapy on functional outcomes after ischemic stroke |
| topic | osteoporosis osteoporosis pharmacotherapy bisphosphonate functional outcomes ischemic stroke |
| url | https://www.mdpi.com/2077-0383/12/15/4905 |
| work_keys_str_mv | AT jongheesohn impactofosteoporosispharmacotherapyonfunctionaloutcomesafterischemicstroke AT chulhokim impactofosteoporosispharmacotherapyonfunctionaloutcomesafterischemicstroke AT yerimkim impactofosteoporosispharmacotherapyonfunctionaloutcomesafterischemicstroke AT soyoungpark impactofosteoporosispharmacotherapyonfunctionaloutcomesafterischemicstroke AT sanghwalee impactofosteoporosispharmacotherapyonfunctionaloutcomesafterischemicstroke |