Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy
Abstract Investigation into the role of cells with respect to extracellular matrix (ECM) remodeling is still in its infancy. Particularly, ECM degradation is an indispensable process during the recovery from fibrosis. Cells with ECM degradation ability due to the secretion of various matrix metallop...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-09-01
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| Series: | Cell Regeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13619-023-00172-9 |
| _version_ | 1797699377150558208 |
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| author | Peng Zhao Tian Sun Cheng Lyu Kaini Liang Yanan Du |
| author_facet | Peng Zhao Tian Sun Cheng Lyu Kaini Liang Yanan Du |
| author_sort | Peng Zhao |
| collection | DOAJ |
| description | Abstract Investigation into the role of cells with respect to extracellular matrix (ECM) remodeling is still in its infancy. Particularly, ECM degradation is an indispensable process during the recovery from fibrosis. Cells with ECM degradation ability due to the secretion of various matrix metalloproteinases (MMPs) have emerged as novel contributors to the treatment of fibrotic diseases. In this review, we focus on the ECM degradation ability of cells associated with the repertoire of MMPs that facilitate the attenuation of fibrosis through the inhibition of ECM deposition. Besides, innovative approaches to engineering and characterizing cells with degradation ability, as well as elucidating the mechanism of the ECM degradation, are also illustrated. Studies conducted to date on the use of cell-based degradation for therapeutic purposes to combat fibrosis are summarized. Finally, we discuss the therapeutic potential of cells with high degradation ability, hoping to bridge the gap between benchside research and bedside applications in treating fibrotic diseases. |
| first_indexed | 2024-03-12T04:07:10Z |
| format | Article |
| id | doaj.art-cf58d95b68554252998fb8e533b6b294 |
| institution | Directory Open Access Journal |
| issn | 2045-9769 |
| language | English |
| last_indexed | 2024-03-12T04:07:10Z |
| publishDate | 2023-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj.art-cf58d95b68554252998fb8e533b6b2942023-09-03T11:16:46ZengSpringerOpenCell Regeneration2045-97692023-09-0112111610.1186/s13619-023-00172-9Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategyPeng Zhao0Tian Sun1Cheng Lyu2Kaini Liang3Yanan Du4Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua UniversityDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua UniversityDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua UniversityDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua UniversityDepartment of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua UniversityAbstract Investigation into the role of cells with respect to extracellular matrix (ECM) remodeling is still in its infancy. Particularly, ECM degradation is an indispensable process during the recovery from fibrosis. Cells with ECM degradation ability due to the secretion of various matrix metalloproteinases (MMPs) have emerged as novel contributors to the treatment of fibrotic diseases. In this review, we focus on the ECM degradation ability of cells associated with the repertoire of MMPs that facilitate the attenuation of fibrosis through the inhibition of ECM deposition. Besides, innovative approaches to engineering and characterizing cells with degradation ability, as well as elucidating the mechanism of the ECM degradation, are also illustrated. Studies conducted to date on the use of cell-based degradation for therapeutic purposes to combat fibrosis are summarized. Finally, we discuss the therapeutic potential of cells with high degradation ability, hoping to bridge the gap between benchside research and bedside applications in treating fibrotic diseases.https://doi.org/10.1186/s13619-023-00172-9FibrosisExtracellular matrixDegradationMatrix metalloproteinases |
| spellingShingle | Peng Zhao Tian Sun Cheng Lyu Kaini Liang Yanan Du Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy Cell Regeneration Fibrosis Extracellular matrix Degradation Matrix metalloproteinases |
| title | Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy |
| title_full | Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy |
| title_fullStr | Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy |
| title_full_unstemmed | Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy |
| title_short | Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy |
| title_sort | cell mediated ecm degradation as an emerging tool for anti fibrotic strategy |
| topic | Fibrosis Extracellular matrix Degradation Matrix metalloproteinases |
| url | https://doi.org/10.1186/s13619-023-00172-9 |
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