Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance.
Cognitive deficits are observed throughout all developmental phases of psychosis. However, prior studies have usually focused on a limited illness period and used a wide variety of cognitive instruments. Therefore, it has been difficult to characterize or highlight cognitive functioning in different...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4431726?pdf=render |
| _version_ | 1819118455257825280 |
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| author | TianHong Zhang HuiJun Li William S Stone Kristen A Woodberry Larry J Seidman YingYing Tang Qian Guo KaiMing Zhuo ZhenYing Qian HuiRu Cui YiKang Zhu LiJuan Jiang Annabelle Chow YunXiang Tang ChunBo Li KaiDa Jiang ZhengHui Yi ZePing Xiao JiJun Wang |
| author_facet | TianHong Zhang HuiJun Li William S Stone Kristen A Woodberry Larry J Seidman YingYing Tang Qian Guo KaiMing Zhuo ZhenYing Qian HuiRu Cui YiKang Zhu LiJuan Jiang Annabelle Chow YunXiang Tang ChunBo Li KaiDa Jiang ZhengHui Yi ZePing Xiao JiJun Wang |
| author_sort | TianHong Zhang |
| collection | DOAJ |
| description | Cognitive deficits are observed throughout all developmental phases of psychosis. However, prior studies have usually focused on a limited illness period and used a wide variety of cognitive instruments. Therefore, it has been difficult to characterize or highlight cognitive functioning in different stages of psychosis.We administered the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) tests to 4 participant subgroups, including healthy volunteers (controls, HC, n = 28), subjects at high risk for clinical psychosis (prodrome, CHR, n = 27), first-episode schizophrenia patients (FE-Sz, n = 26), and mid-term and long-term chronic schizophrenia patients (Ch-Sz, n =147). Comparison, correlation, and regression analyses of RBANS index scores were assessed among groups. We examined clinical outcomes over 2 years between the CHR and HC subjects, and RBANS domains were used as possible predictors for conversion to psychosis.Performance on all RBANS domains was significantly impaired during a post-onset stage of psychosis (FE-Sz and Ch-Sz), and RBANS scores declined along with disease progression. Regression analyses showed that for CHR and HC subjects, baseline impairment in delayed memory (DM) significantly predicted conversion to psychosis. Additionally, partial correlations showed that for FE-Sz and Ch-Sz subjects, DM was the only correlate with a later stage of psychosis.Cognitive deficits broadly emerged, and diminished functioning followed along with disease progression. Impairment in DM is perhaps one domain that helps us understand the development of psychosis. A critical need is to monitor and treat memory functioning for psychotic patients throughout all phases of the disease. |
| first_indexed | 2024-12-22T05:49:09Z |
| format | Article |
| id | doaj.art-cf58da2028f24a8cb41c8baf868d38df |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T05:49:09Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cf58da2028f24a8cb41c8baf868d38df2022-12-21T18:36:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012578410.1371/journal.pone.0125784Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance.TianHong ZhangHuiJun LiWilliam S StoneKristen A WoodberryLarry J SeidmanYingYing TangQian GuoKaiMing ZhuoZhenYing QianHuiRu CuiYiKang ZhuLiJuan JiangAnnabelle ChowYunXiang TangChunBo LiKaiDa JiangZhengHui YiZePing XiaoJiJun WangCognitive deficits are observed throughout all developmental phases of psychosis. However, prior studies have usually focused on a limited illness period and used a wide variety of cognitive instruments. Therefore, it has been difficult to characterize or highlight cognitive functioning in different stages of psychosis.We administered the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) tests to 4 participant subgroups, including healthy volunteers (controls, HC, n = 28), subjects at high risk for clinical psychosis (prodrome, CHR, n = 27), first-episode schizophrenia patients (FE-Sz, n = 26), and mid-term and long-term chronic schizophrenia patients (Ch-Sz, n =147). Comparison, correlation, and regression analyses of RBANS index scores were assessed among groups. We examined clinical outcomes over 2 years between the CHR and HC subjects, and RBANS domains were used as possible predictors for conversion to psychosis.Performance on all RBANS domains was significantly impaired during a post-onset stage of psychosis (FE-Sz and Ch-Sz), and RBANS scores declined along with disease progression. Regression analyses showed that for CHR and HC subjects, baseline impairment in delayed memory (DM) significantly predicted conversion to psychosis. Additionally, partial correlations showed that for FE-Sz and Ch-Sz subjects, DM was the only correlate with a later stage of psychosis.Cognitive deficits broadly emerged, and diminished functioning followed along with disease progression. Impairment in DM is perhaps one domain that helps us understand the development of psychosis. A critical need is to monitor and treat memory functioning for psychotic patients throughout all phases of the disease.http://europepmc.org/articles/PMC4431726?pdf=render |
| spellingShingle | TianHong Zhang HuiJun Li William S Stone Kristen A Woodberry Larry J Seidman YingYing Tang Qian Guo KaiMing Zhuo ZhenYing Qian HuiRu Cui YiKang Zhu LiJuan Jiang Annabelle Chow YunXiang Tang ChunBo Li KaiDa Jiang ZhengHui Yi ZePing Xiao JiJun Wang Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance. PLoS ONE |
| title | Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance. |
| title_full | Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance. |
| title_fullStr | Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance. |
| title_full_unstemmed | Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance. |
| title_short | Neuropsychological Impairment in Prodromal, First-Episode, and Chronic Psychosis: Assessing RBANS Performance. |
| title_sort | neuropsychological impairment in prodromal first episode and chronic psychosis assessing rbans performance |
| url | http://europepmc.org/articles/PMC4431726?pdf=render |
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