A brief review of relationship between occupational benzene exposure and hematopoietic cancer
Abstract We reviewed articles to clarify the current evidence status for 1) types of cancer which related to benzene exposure, and 2) certain benzene exposure level which might cause the hematopoietic cancers. Hematopoietic function of the bone marrow is involved in the production of all blood cells...
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| Format: | Article |
| Language: | English |
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Korean Society of Occupational & Environmental Medicine
2018-05-01
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| Series: | Annals of Occupational and Environmental Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40557-018-0245-9 |
| _version_ | 1818018144443170816 |
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| author | Jin-Ha Yoon Woo Seok Kwak Yeon-Soon Ahn |
| author_facet | Jin-Ha Yoon Woo Seok Kwak Yeon-Soon Ahn |
| author_sort | Jin-Ha Yoon |
| collection | DOAJ |
| description | Abstract We reviewed articles to clarify the current evidence status for 1) types of cancer which related to benzene exposure, and 2) certain benzene exposure level which might cause the hematopoietic cancers. Hematopoietic function of the bone marrow is involved in the production of all blood cells types. The benzene metabolites including benzoquinone and mucoaldehyde affect hematopoietic stem cells as well as differentiation steps of progenitor cells for each blood cell. Hence, we concluded that benzene was associated with all lymphohematic carcinogenesis. First, it is supported by biological plausibility. Second, it is supported by meta-analysis although sing study did not show relationship due to lack of sample size or statistical power. More recent studies show lesser exposed level related to risk of cancer, compare to past studies did. Actually, early studies show the risk of malignancies in workers who exposed more than 200 ppm-years. However, only 0.5 to 1 ppm-year benzene exposed show significant linking to risk of malignancies in recent study. As reviewed research articles, we concluded that the relatively lower exposure level, such as 0.5–1 ppm-year, will be considering at risk of hematopoietic cancer. However, more research needs to be done on dose-response analysis. |
| first_indexed | 2024-04-14T07:36:05Z |
| format | Article |
| id | doaj.art-cf5929be7e93405b86c59ccd628b042b |
| institution | Directory Open Access Journal |
| issn | 2052-4374 |
| language | English |
| last_indexed | 2024-04-14T07:36:05Z |
| publishDate | 2018-05-01 |
| publisher | Korean Society of Occupational & Environmental Medicine |
| record_format | Article |
| series | Annals of Occupational and Environmental Medicine |
| spelling | doaj.art-cf5929be7e93405b86c59ccd628b042b2022-12-22T02:05:41ZengKorean Society of Occupational & Environmental MedicineAnnals of Occupational and Environmental Medicine2052-43742018-05-013011510.1186/s40557-018-0245-9A brief review of relationship between occupational benzene exposure and hematopoietic cancerJin-Ha Yoon0Woo Seok Kwak1Yeon-Soon Ahn2Department of Preventive Medicine, Yonsei University College of MedicineThe Institute for Occupational Health, Yonsei University College of MedicineDepartment of Preventive Medicine, Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of MedicineAbstract We reviewed articles to clarify the current evidence status for 1) types of cancer which related to benzene exposure, and 2) certain benzene exposure level which might cause the hematopoietic cancers. Hematopoietic function of the bone marrow is involved in the production of all blood cells types. The benzene metabolites including benzoquinone and mucoaldehyde affect hematopoietic stem cells as well as differentiation steps of progenitor cells for each blood cell. Hence, we concluded that benzene was associated with all lymphohematic carcinogenesis. First, it is supported by biological plausibility. Second, it is supported by meta-analysis although sing study did not show relationship due to lack of sample size or statistical power. More recent studies show lesser exposed level related to risk of cancer, compare to past studies did. Actually, early studies show the risk of malignancies in workers who exposed more than 200 ppm-years. However, only 0.5 to 1 ppm-year benzene exposed show significant linking to risk of malignancies in recent study. As reviewed research articles, we concluded that the relatively lower exposure level, such as 0.5–1 ppm-year, will be considering at risk of hematopoietic cancer. However, more research needs to be done on dose-response analysis.http://link.springer.com/article/10.1186/s40557-018-0245-9BenzeneHematopoietic cancerLeukemia |
| spellingShingle | Jin-Ha Yoon Woo Seok Kwak Yeon-Soon Ahn A brief review of relationship between occupational benzene exposure and hematopoietic cancer Annals of Occupational and Environmental Medicine Benzene Hematopoietic cancer Leukemia |
| title | A brief review of relationship between occupational benzene exposure and hematopoietic cancer |
| title_full | A brief review of relationship between occupational benzene exposure and hematopoietic cancer |
| title_fullStr | A brief review of relationship between occupational benzene exposure and hematopoietic cancer |
| title_full_unstemmed | A brief review of relationship between occupational benzene exposure and hematopoietic cancer |
| title_short | A brief review of relationship between occupational benzene exposure and hematopoietic cancer |
| title_sort | brief review of relationship between occupational benzene exposure and hematopoietic cancer |
| topic | Benzene Hematopoietic cancer Leukemia |
| url | http://link.springer.com/article/10.1186/s40557-018-0245-9 |
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