Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil
Invasive pneumococcal disease is a relevant public health problem in Brazil, especially among children and the elderly. In July/2010 a 10-valent pneumococcal conjugate vaccine was introduced to the immunization schedule of Brazilian children under two years of age. Between July/2010 and December/201...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S141386701500210X |
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| author | Carolina Regis Leite Jailton Azevedo Vivian Santos Galvão Otávio Moreno-Carvalho Joice Neves Reis Cristiana Nascimento-Carvalho |
| author_facet | Carolina Regis Leite Jailton Azevedo Vivian Santos Galvão Otávio Moreno-Carvalho Joice Neves Reis Cristiana Nascimento-Carvalho |
| author_sort | Carolina Regis Leite |
| collection | DOAJ |
| description | Invasive pneumococcal disease is a relevant public health problem in Brazil, especially among children and the elderly. In July/2010 a 10-valent pneumococcal conjugate vaccine was introduced to the immunization schedule of Brazilian children under two years of age. Between July/2010 and December/2013 we conducted a case-series study on invasive pneumococcal disease in Salvador, Brazil to describe the clinical and bacteriological profile of invasive pneumococcal disease cases during the post-implementation period. Eighty-two cases were eligible. Mean age was 31 years (interquartile range, 3–42); 17.1% and 30.5% were under 2 years and 5 years, respectively. Pneumococcal meningitis (n = 64, 78.1%), bacteraemic pneumococcal pneumonia (n = 12, 14.6%) and bacteraemia (n = 6, 7.3%) were the clinical syndromes identified. Thirty-three different serotypes were found. Of these, serotype 14 (n = 12, 14.6%) was the most common, followed by 23F (n = 10, 12.2%), 12F (n = 8, 9.8%), 18 C (n = 5, 6.1%) and 6B (n = 5, 6.1%). Investigations conducted in Salvador in the pre-vaccine period did not identify serotype 12F as one of the most prevalent serotypes. Increase of serotype 12F was observed in different regions of Brazil, in the post-vaccine period. Among children under two years of age, the target group for 10-valent pneumococcal conjugate vaccine, 11 (78.6%) of the 14 isolated strains of Streptococcus pneumoniae belonged to vaccine serotypes; at least 50% of these children were not vaccinated. The relatively recent implementation of 10-valent pneumococcal conjugate vaccine in Brazil reinforces the need to maintain an active surveillance of invasive pneumococcal disease cases, considering the possible increase of invasive pneumococcal disease cases related to non-vaccine serotypes and the changes on the clinical presentation of the disease. Keywords: Streptococcus pneumoniae, Vaccine, Epidemiology |
| first_indexed | 2024-12-20T23:54:34Z |
| format | Article |
| id | doaj.art-cf599a9f863d4265adbe25e28c23df5f |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-20T23:54:34Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-cf599a9f863d4265adbe25e28c23df5f2022-12-21T19:22:45ZengElsevierBrazilian Journal of Infectious Diseases1413-86702016-01-012015660S1413-86702016000100056Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, BrazilCarolina Regis Leite0Jailton Azevedo1Vivian Santos Galvão2Otávio Moreno-Carvalho3Joice Neves Reis4Cristiana Nascimento-Carvalho5Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BA, Brazil; Corresponding author.Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, BrazilLaboratório de líquor–SINPEL/Fundação José Silveira, Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil; Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, BA, BrazilFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BA, BrazilInvasive pneumococcal disease is a relevant public health problem in Brazil, especially among children and the elderly. In July/2010 a 10-valent pneumococcal conjugate vaccine was introduced to the immunization schedule of Brazilian children under two years of age. Between July/2010 and December/2013 we conducted a case-series study on invasive pneumococcal disease in Salvador, Brazil to describe the clinical and bacteriological profile of invasive pneumococcal disease cases during the post-implementation period. Eighty-two cases were eligible. Mean age was 31 years (interquartile range, 3–42); 17.1% and 30.5% were under 2 years and 5 years, respectively. Pneumococcal meningitis (n = 64, 78.1%), bacteraemic pneumococcal pneumonia (n = 12, 14.6%) and bacteraemia (n = 6, 7.3%) were the clinical syndromes identified. Thirty-three different serotypes were found. Of these, serotype 14 (n = 12, 14.6%) was the most common, followed by 23F (n = 10, 12.2%), 12F (n = 8, 9.8%), 18 C (n = 5, 6.1%) and 6B (n = 5, 6.1%). Investigations conducted in Salvador in the pre-vaccine period did not identify serotype 12F as one of the most prevalent serotypes. Increase of serotype 12F was observed in different regions of Brazil, in the post-vaccine period. Among children under two years of age, the target group for 10-valent pneumococcal conjugate vaccine, 11 (78.6%) of the 14 isolated strains of Streptococcus pneumoniae belonged to vaccine serotypes; at least 50% of these children were not vaccinated. The relatively recent implementation of 10-valent pneumococcal conjugate vaccine in Brazil reinforces the need to maintain an active surveillance of invasive pneumococcal disease cases, considering the possible increase of invasive pneumococcal disease cases related to non-vaccine serotypes and the changes on the clinical presentation of the disease. Keywords: Streptococcus pneumoniae, Vaccine, Epidemiologyhttp://www.sciencedirect.com/science/article/pii/S141386701500210X |
| spellingShingle | Carolina Regis Leite Jailton Azevedo Vivian Santos Galvão Otávio Moreno-Carvalho Joice Neves Reis Cristiana Nascimento-Carvalho Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil Brazilian Journal of Infectious Diseases |
| title | Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil |
| title_full | Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil |
| title_fullStr | Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil |
| title_full_unstemmed | Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil |
| title_short | Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil |
| title_sort | clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10 valent conjugate vaccine implementation in salvador brazil |
| url | http://www.sciencedirect.com/science/article/pii/S141386701500210X |
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