Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma, the most common type of oral cancer, affects more than 275,000 people per year worldwide. Oral squamous cell carcinoma is very aggressive, as most patients die after 3 to 5 years post-diagnosis. The initiation and progression of oral squamous cell carcinoma are multifac...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.602661/full |
| _version_ | 1818565940965539840 |
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| author | Daniel Peña-Oyarzún Daniel Peña-Oyarzún Daniel Peña-Oyarzún Daniel Peña-Oyarzún Montserrat Reyes María Paz Hernández-Cáceres María Paz Hernández-Cáceres Catalina Kretschmar Catalina Kretschmar Catalina Kretschmar Eugenia Morselli Eugenia Morselli Cesar A. Ramirez-Sarmiento Sergio Lavandero Sergio Lavandero Vicente A. Torres Vicente A. Torres Alfredo Criollo Alfredo Criollo Alfredo Criollo |
| author_facet | Daniel Peña-Oyarzún Daniel Peña-Oyarzún Daniel Peña-Oyarzún Daniel Peña-Oyarzún Montserrat Reyes María Paz Hernández-Cáceres María Paz Hernández-Cáceres Catalina Kretschmar Catalina Kretschmar Catalina Kretschmar Eugenia Morselli Eugenia Morselli Cesar A. Ramirez-Sarmiento Sergio Lavandero Sergio Lavandero Vicente A. Torres Vicente A. Torres Alfredo Criollo Alfredo Criollo Alfredo Criollo |
| author_sort | Daniel Peña-Oyarzún |
| collection | DOAJ |
| description | Oral squamous cell carcinoma, the most common type of oral cancer, affects more than 275,000 people per year worldwide. Oral squamous cell carcinoma is very aggressive, as most patients die after 3 to 5 years post-diagnosis. The initiation and progression of oral squamous cell carcinoma are multifactorial: smoking, alcohol consumption, and human papilloma virus infection are among the causes that promote its development. Although oral squamous cell carcinoma involves abnormal growth and migration of oral epithelial cells, other cell types such as fibroblasts and immune cells form the carcinoma niche. An underlying inflammatory state within the oral tissue promotes differential stress-related responses that favor oral squamous cell carcinoma. Autophagy is an intracellular degradation process that allows cancer cells to survive under stress conditions. Autophagy degrades cellular components by sequestering them in vesicles called autophagosomes, which ultimately fuse with lysosomes. Although several autophagy markers have been associated with oral squamous cell carcinoma, it remains unclear whether up- or down-regulation of autophagy favors its progression. Autophagy levels during oral squamous cell carcinoma are both timing- and cell-specific. Here we discuss how autophagy is required to establish a new cellular microenvironment in oral squamous cell carcinoma and how autophagy drives the phenotypic change of oral squamous cell carcinoma cells by promoting crosstalk between carcinoma cells, fibroblasts, and immune cells. |
| first_indexed | 2024-12-14T01:47:19Z |
| format | Article |
| id | doaj.art-cf5b8b962bfe4cb5b5d21a470b8dc927 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T01:47:19Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-cf5b8b962bfe4cb5b5d21a470b8dc9272022-12-21T23:21:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.602661602661Role of Autophagy in the Microenvironment of Oral Squamous Cell CarcinomaDaniel Peña-Oyarzún0Daniel Peña-Oyarzún1Daniel Peña-Oyarzún2Daniel Peña-Oyarzún3Montserrat Reyes4María Paz Hernández-Cáceres5María Paz Hernández-Cáceres6Catalina Kretschmar7Catalina Kretschmar8Catalina Kretschmar9Eugenia Morselli10Eugenia Morselli11Cesar A. Ramirez-Sarmiento12Sergio Lavandero13Sergio Lavandero14Vicente A. Torres15Vicente A. Torres16Alfredo Criollo17Alfredo Criollo18Alfredo Criollo19Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, ChileFacultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, ChileAutophagy Research Center, Universidad de Chile, Santiago, ChileDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Patología y Medicina Oral, Facultad de Odontología, Universidad de Chile, Santiago, ChileAutophagy Research Center, Universidad de Chile, Santiago, ChileDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileAdvanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, ChileFacultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, ChileAutophagy Research Center, Universidad de Chile, Santiago, ChileAutophagy Research Center, Universidad de Chile, Santiago, ChileDepartamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileFacultades de Ingenieria, Medicina y Ciencias Biológicas, Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, ChileAdvanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, ChileCardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United StatesAdvanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, ChileFacultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, ChileAdvanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas & Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, ChileFacultad de Odontología, Instituto de Investigación en Ciencias Odontológicas, Universidad de Chile, Santiago, ChileAutophagy Research Center, Universidad de Chile, Santiago, ChileOral squamous cell carcinoma, the most common type of oral cancer, affects more than 275,000 people per year worldwide. Oral squamous cell carcinoma is very aggressive, as most patients die after 3 to 5 years post-diagnosis. The initiation and progression of oral squamous cell carcinoma are multifactorial: smoking, alcohol consumption, and human papilloma virus infection are among the causes that promote its development. Although oral squamous cell carcinoma involves abnormal growth and migration of oral epithelial cells, other cell types such as fibroblasts and immune cells form the carcinoma niche. An underlying inflammatory state within the oral tissue promotes differential stress-related responses that favor oral squamous cell carcinoma. Autophagy is an intracellular degradation process that allows cancer cells to survive under stress conditions. Autophagy degrades cellular components by sequestering them in vesicles called autophagosomes, which ultimately fuse with lysosomes. Although several autophagy markers have been associated with oral squamous cell carcinoma, it remains unclear whether up- or down-regulation of autophagy favors its progression. Autophagy levels during oral squamous cell carcinoma are both timing- and cell-specific. Here we discuss how autophagy is required to establish a new cellular microenvironment in oral squamous cell carcinoma and how autophagy drives the phenotypic change of oral squamous cell carcinoma cells by promoting crosstalk between carcinoma cells, fibroblasts, and immune cells.https://www.frontiersin.org/articles/10.3389/fonc.2020.602661/fulloral squamous cell carcinomaautophagytumor microenvironmentcancercarcinoma-associated fibroblast |
| spellingShingle | Daniel Peña-Oyarzún Daniel Peña-Oyarzún Daniel Peña-Oyarzún Daniel Peña-Oyarzún Montserrat Reyes María Paz Hernández-Cáceres María Paz Hernández-Cáceres Catalina Kretschmar Catalina Kretschmar Catalina Kretschmar Eugenia Morselli Eugenia Morselli Cesar A. Ramirez-Sarmiento Sergio Lavandero Sergio Lavandero Vicente A. Torres Vicente A. Torres Alfredo Criollo Alfredo Criollo Alfredo Criollo Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma Frontiers in Oncology oral squamous cell carcinoma autophagy tumor microenvironment cancer carcinoma-associated fibroblast |
| title | Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma |
| title_full | Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma |
| title_fullStr | Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma |
| title_short | Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma |
| title_sort | role of autophagy in the microenvironment of oral squamous cell carcinoma |
| topic | oral squamous cell carcinoma autophagy tumor microenvironment cancer carcinoma-associated fibroblast |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.602661/full |
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