Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes
Four new complexes derived from adamantly containing hydrazone (<b>APH</b>) ligand with Cu(II) (<b>1</b>), Co(II) (<b>2</b>), Ni(II) (<b>3</b>) and Zn(II) (<b>4</b>), have been synthesized and characterized using different physicochemical m...
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| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/11/2530 |
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| author | Ihsan A. Shehadi Fatima-Azzahra Delmani Areej M. Jaber Hana Hammad Murad A. AlDamen Raed A. Al-Qawasmeh Monther A. Khanfar |
| author_facet | Ihsan A. Shehadi Fatima-Azzahra Delmani Areej M. Jaber Hana Hammad Murad A. AlDamen Raed A. Al-Qawasmeh Monther A. Khanfar |
| author_sort | Ihsan A. Shehadi |
| collection | DOAJ |
| description | Four new complexes derived from adamantly containing hydrazone (<b>APH</b>) ligand with Cu(II) (<b>1</b>), Co(II) (<b>2</b>), Ni(II) (<b>3</b>) and Zn(II) (<b>4</b>), have been synthesized and characterized using different physicochemical methods. The structure of the ligand <b>APH</b> and its copper complex <b>1</b> have been established by single-crystal X-ray diffraction direct methods, which reveal that complex <b>1</b> has distorted square-pyramidal geometry. Complexes <b>1</b>–<b>4</b> are screened against seven human cancer cell lines namely, breast cancer cell lines (MCF7, T47D, MDA-MB-231), prostate cancer cell lines (PC3, DU145) and the colorectal cancer cell line Coco-2, for their antiproliferative activities. Complex <b>1</b> has shown a promising anticancer activity compared to the other ones. The structural and spectroscopic analysis of <b>APH</b> and its complexes are confirmed by DFT calculations. |
| first_indexed | 2024-03-10T19:31:04Z |
| format | Article |
| id | doaj.art-cf5c60b47528437fba805946fe601656 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:31:04Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cf5c60b47528437fba805946fe6016562023-11-20T02:09:22ZengMDPI AGMolecules1420-30492020-05-012511253010.3390/molecules25112530Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone ComplexesIhsan A. Shehadi0Fatima-Azzahra Delmani1Areej M. Jaber2Hana Hammad3Murad A. AlDamen4Raed A. Al-Qawasmeh5Monther A. Khanfar6Department of Chemistry, Faculty of Sciences, University of Sharjah, Sharjah 27272, UAEDepartment of Biology, Faculty of Science, Jerash University, Jerash 26150, JordanDepartment of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, JordanDepartment of Biology, Faculty of Science, The University of Jordan, Amman 11942, JordanDepartment of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, JordanDepartment of Chemistry, Faculty of Sciences, University of Sharjah, Sharjah 27272, UAEDepartment of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, JordanFour new complexes derived from adamantly containing hydrazone (<b>APH</b>) ligand with Cu(II) (<b>1</b>), Co(II) (<b>2</b>), Ni(II) (<b>3</b>) and Zn(II) (<b>4</b>), have been synthesized and characterized using different physicochemical methods. The structure of the ligand <b>APH</b> and its copper complex <b>1</b> have been established by single-crystal X-ray diffraction direct methods, which reveal that complex <b>1</b> has distorted square-pyramidal geometry. Complexes <b>1</b>–<b>4</b> are screened against seven human cancer cell lines namely, breast cancer cell lines (MCF7, T47D, MDA-MB-231), prostate cancer cell lines (PC3, DU145) and the colorectal cancer cell line Coco-2, for their antiproliferative activities. Complex <b>1</b> has shown a promising anticancer activity compared to the other ones. The structural and spectroscopic analysis of <b>APH</b> and its complexes are confirmed by DFT calculations.https://www.mdpi.com/1420-3049/25/11/25302-pyridyl adamantanhydrazonehydrazone complexesantitumorcrystal structure |
| spellingShingle | Ihsan A. Shehadi Fatima-Azzahra Delmani Areej M. Jaber Hana Hammad Murad A. AlDamen Raed A. Al-Qawasmeh Monther A. Khanfar Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes Molecules 2-pyridyl adamantanhydrazone hydrazone complexes antitumor crystal structure |
| title | Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes |
| title_full | Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes |
| title_fullStr | Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes |
| title_full_unstemmed | Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes |
| title_short | Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes |
| title_sort | synthesis characterization and biological evaluation of metal adamantyl 2 pyridylhydrazone complexes |
| topic | 2-pyridyl adamantanhydrazone hydrazone complexes antitumor crystal structure |
| url | https://www.mdpi.com/1420-3049/25/11/2530 |
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