Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic Horses
Roan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/6/680 |
| _version_ | 1797564470409560064 |
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| author | Katharina Voß Julia Tetens Georg Thaller Doreen Becker |
| author_facet | Katharina Voß Julia Tetens Georg Thaller Doreen Becker |
| author_sort | Katharina Voß |
| collection | DOAJ |
| description | Roan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-roan ratio of foals from roan × roan matings revealed homozygous roan Icelandic horses to be viable. Even though roan is known to be inherited in a dominant mode and epistatic to other coat colors, the causative mutation is still unknown. Nevertheless, an association between roan phenotype and the <i>KIT</i> gene was shown for different horse breeds. In the present study, we identified <i>KIT</i> variants by Sanger sequencing, and show that <i>KIT</i> is also associated with roan in the Icelandic horse breed. |
| first_indexed | 2024-03-10T18:58:41Z |
| format | Article |
| id | doaj.art-cf5ddbfcaa6a423dbd389b95d5930aca |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T18:58:41Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-cf5ddbfcaa6a423dbd389b95d5930aca2023-11-20T04:36:31ZengMDPI AGGenes2073-44252020-06-0111668010.3390/genes11060680Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic HorsesKatharina Voß0Julia Tetens1Georg Thaller2Doreen Becker3Institute of Animal Breeding and Husbandry, University of Kiel, Olshausenstraße 40, 24098 Kiel, GermanyInstitute of Animal Breeding and Husbandry, University of Kiel, Olshausenstraße 40, 24098 Kiel, GermanyInstitute of Animal Breeding and Husbandry, University of Kiel, Olshausenstraße 40, 24098 Kiel, GermanyInstitute of Genome Biology, Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, GermanyRoan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-roan ratio of foals from roan × roan matings revealed homozygous roan Icelandic horses to be viable. Even though roan is known to be inherited in a dominant mode and epistatic to other coat colors, the causative mutation is still unknown. Nevertheless, an association between roan phenotype and the <i>KIT</i> gene was shown for different horse breeds. In the present study, we identified <i>KIT</i> variants by Sanger sequencing, and show that <i>KIT</i> is also associated with roan in the Icelandic horse breed.https://www.mdpi.com/2073-4425/11/6/680coat colorroanIcelandic horse |
| spellingShingle | Katharina Voß Julia Tetens Georg Thaller Doreen Becker Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic Horses Genes coat color roan Icelandic horse |
| title | Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic Horses |
| title_full | Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic Horses |
| title_fullStr | Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic Horses |
| title_full_unstemmed | Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic Horses |
| title_short | Coat Color Roan Shows Association with <i>KIT</i> Variants and No Evidence of Lethality in Icelandic Horses |
| title_sort | coat color roan shows association with i kit i variants and no evidence of lethality in icelandic horses |
| topic | coat color roan Icelandic horse |
| url | https://www.mdpi.com/2073-4425/11/6/680 |
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