Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway
Nonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world’s population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic targ...
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MDPI AG
2021-04-01
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| Online Access: | https://www.mdpi.com/1420-3049/26/9/2434 |
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| author | Jitendra Shrestha Dong-Jae Baek Yoon-Sin Oh Sam-Seok Cho Sung-Hwan Ki Eun-Young Park |
| author_facet | Jitendra Shrestha Dong-Jae Baek Yoon-Sin Oh Sam-Seok Cho Sung-Hwan Ki Eun-Young Park |
| author_sort | Jitendra Shrestha |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world’s population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic target has not been developed yet. Previously, there have been reports on the benefits of <i>Cudrania tricuspidata</i> (CT) for treating obesity and diabetes via regulation of metabolic processes, such as lipogenesis, lipolysis, and inflammation. In this study, we investigated the ameliorative effect of orally administered 0.25% and 0.5% (<i>w</i>/<i>w</i>) CT mixed with high-fat diet (HFD) to C57BL/6J mice for 7 weeks. It was found that body weight, fat mass, hepatic mass, serum glucose level, and liver cholesterol levels were significantly reduced after CT treatment. In CT-treated HFD-fed mice, the mRNA expression levels of hepatic lipogenic and inflammatory cytokine-related genes were markedly reduced, whereas the expression level of epididymal lipogenic genes was increased. The mRNA expression level of beta-oxidation and Nrf-2/HO-1 genes significantly increased in CT-treated obese mice livers. We propose that CT alleviates hepatic steatosis by reducing oxidative stress and inflammation. |
| first_indexed | 2024-03-10T12:06:06Z |
| format | Article |
| id | doaj.art-cf5e0bfd84c5449f8cb553847b73bf31 |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:06:06Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cf5e0bfd84c5449f8cb553847b73bf312023-11-21T16:38:09ZengMDPI AGMolecules1420-30492021-04-01269243410.3390/molecules26092434Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 PathwayJitendra Shrestha0Dong-Jae Baek1Yoon-Sin Oh2Sam-Seok Cho3Sung-Hwan Ki4Eun-Young Park5College of Pharmacy, Mokpo National University, Jeonnam 58554, KoreaCollege of Pharmacy, Mokpo National University, Jeonnam 58554, KoreaDepartment of Food and Nutrition, Eulji University, Seongnam 13135, KoreaCollege of Pharmacy, Chosun University, Gwangju 61452, KoreaCollege of Pharmacy, Chosun University, Gwangju 61452, KoreaCollege of Pharmacy, Mokpo National University, Jeonnam 58554, KoreaNonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world’s population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic target has not been developed yet. Previously, there have been reports on the benefits of <i>Cudrania tricuspidata</i> (CT) for treating obesity and diabetes via regulation of metabolic processes, such as lipogenesis, lipolysis, and inflammation. In this study, we investigated the ameliorative effect of orally administered 0.25% and 0.5% (<i>w</i>/<i>w</i>) CT mixed with high-fat diet (HFD) to C57BL/6J mice for 7 weeks. It was found that body weight, fat mass, hepatic mass, serum glucose level, and liver cholesterol levels were significantly reduced after CT treatment. In CT-treated HFD-fed mice, the mRNA expression levels of hepatic lipogenic and inflammatory cytokine-related genes were markedly reduced, whereas the expression level of epididymal lipogenic genes was increased. The mRNA expression level of beta-oxidation and Nrf-2/HO-1 genes significantly increased in CT-treated obese mice livers. We propose that CT alleviates hepatic steatosis by reducing oxidative stress and inflammation.https://www.mdpi.com/1420-3049/26/9/2434nonalcoholic fatty liver disease<i>Cudrania tricuspidata</i>antioxidantnuclear factorerythroid 2 like 2 |
| spellingShingle | Jitendra Shrestha Dong-Jae Baek Yoon-Sin Oh Sam-Seok Cho Sung-Hwan Ki Eun-Young Park Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway Molecules nonalcoholic fatty liver disease <i>Cudrania tricuspidata</i> antioxidant nuclear factor erythroid 2 like 2 |
| title | Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway |
| title_full | Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway |
| title_fullStr | Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway |
| title_full_unstemmed | Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway |
| title_short | Protective Effect of <i>Cudrania tricuspidata</i> Extract against High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through Nrf-2/HO-1 Pathway |
| title_sort | protective effect of i cudrania tricuspidata i extract against high fat diet induced nonalcoholic fatty liver disease through nrf 2 ho 1 pathway |
| topic | nonalcoholic fatty liver disease <i>Cudrania tricuspidata</i> antioxidant nuclear factor erythroid 2 like 2 |
| url | https://www.mdpi.com/1420-3049/26/9/2434 |
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