Persistent Nonviral Plasmid Vector in Nasal Tissues Causes False-Positive SARS-CoV-2 Diagnostic Nucleic Acid Tests

Persistent Nonviral Plasmid Vector in Nasal Tissues Causes False-Positive SARS-CoV-2 Diagnostic Nucleic Acid Tests

ABSTRACT Biomedical personnel can become contaminated with nonhazardous reagents used in the laboratory. We describe molecular studies performed on nasal secretions collected longitudinally from asymptomatic laboratory coworkers to determine if they were infected with severe acute respiratory syndro...

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Bibliographic Details
Main Authors: Ingrid A. Beck, Sheila Styrchak, Leslie Miller, Fred Mast, Vladimir Vigdorovich, Winnie Yeung, Daisy Ko, Alyssa Oldroyd, Samantha Hardy, Song Li, John Houck, Yonghou Jiang, Nicholas Dambrauskas, Catherine Darcey, Andrew Raappana, William Selman, D. Noah Sather, John D. Aitchison, Whitney E. Harrington, Lisa M. Frenkel
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
plasmid vector
nasal swab
diagnostic test
false test result
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01695-22

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