Neutrophilic hyperleukocytosis in the multiple myeloma onset
Neutrophilic leukocytosis is not specific for multiple myeloma (MM) and is a reason for the exclusion of myeloproliferative neoplasm.A clinical case of MM patient with neutrophilic hyperleukocytosis (75 х 109/L), liver and spleen enlargement at the disease onset is presented. Examination did not rev...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/561 |
| _version_ | 1797855502160363520 |
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| author | I. G. Rekhtina L. Yu. Kolosova V. A. Khyshova A. M. Kovrigina L. P. Mendeleeva |
| author_facet | I. G. Rekhtina L. Yu. Kolosova V. A. Khyshova A. M. Kovrigina L. P. Mendeleeva |
| author_sort | I. G. Rekhtina |
| collection | DOAJ |
| description | Neutrophilic leukocytosis is not specific for multiple myeloma (MM) and is a reason for the exclusion of myeloproliferative neoplasm.A clinical case of MM patient with neutrophilic hyperleukocytosis (75 х 109/L), liver and spleen enlargement at the disease onset is presented. Examination did not reveal t(9;22), BCR/ABL gene and JAK2V617F mutation. To exclude the combination of MM with chronic neutrophilic leukemia, a study of the clinically significant part of the CSFR3R gene was performed. The absence of a CSFR3R gene mutation made it possible to exclude chronic neutrophilic leukemia and start MM treatment. After the 1st therapy course with bortezomib, cyclophosphamide and dexamethasone, blood counts returned to normal, liver and spleen size decreased. After 6 therapy courses, complete hematological remission was achieved. An attempt to mobilize peripheral blood stem cells with cyclophosphamide was unsuccessful. The effectiveness of antimyeloma therapy proved the correctness of the diagnosis and the chosen treatment tactics.Neutrophilic leukocytosis in MM is explained by the ability of plasma cells to synthesize granulocyte colony-stimulating factor in some cases. In the presence of a plasma cell tumor, the analysis of the CSFR3R gene may be of decisive importance in the differential diagnosis of reactive neutrophilic leukocytosis due to MM and the combination of MM with chronic neutrophilic leukemia. |
| first_indexed | 2024-04-09T20:24:42Z |
| format | Article |
| id | doaj.art-cf5f3282a05e4d4b80e01f53f5234f8c |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:24:42Z |
| publishDate | 2022-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-cf5f3282a05e4d4b80e01f53f5234f8c2023-03-30T20:15:14ZrusABV-pressОнкогематология1818-83462413-40232022-07-01173838810.17650/1818-8346-2022-17-3-83-88454Neutrophilic hyperleukocytosis in the multiple myeloma onsetI. G. Rekhtina0L. Yu. Kolosova1V. A. Khyshova2A. M. Kovrigina3L. P. Mendeleeva4National Research Center for Hematology, Ministry of Health of RussiaNational Research Center for Hematology, Ministry of Health of RussiaNational Research Center for Hematology, Ministry of Health of RussiaNational Research Center for Hematology, Ministry of Health of RussiaNational Research Center for Hematology, Ministry of Health of RussiaNeutrophilic leukocytosis is not specific for multiple myeloma (MM) and is a reason for the exclusion of myeloproliferative neoplasm.A clinical case of MM patient with neutrophilic hyperleukocytosis (75 х 109/L), liver and spleen enlargement at the disease onset is presented. Examination did not reveal t(9;22), BCR/ABL gene and JAK2V617F mutation. To exclude the combination of MM with chronic neutrophilic leukemia, a study of the clinically significant part of the CSFR3R gene was performed. The absence of a CSFR3R gene mutation made it possible to exclude chronic neutrophilic leukemia and start MM treatment. After the 1st therapy course with bortezomib, cyclophosphamide and dexamethasone, blood counts returned to normal, liver and spleen size decreased. After 6 therapy courses, complete hematological remission was achieved. An attempt to mobilize peripheral blood stem cells with cyclophosphamide was unsuccessful. The effectiveness of antimyeloma therapy proved the correctness of the diagnosis and the chosen treatment tactics.Neutrophilic leukocytosis in MM is explained by the ability of plasma cells to synthesize granulocyte colony-stimulating factor in some cases. In the presence of a plasma cell tumor, the analysis of the CSFR3R gene may be of decisive importance in the differential diagnosis of reactive neutrophilic leukocytosis due to MM and the combination of MM with chronic neutrophilic leukemia.https://oncohematology.abvpress.ru/ongm/article/view/561multiple myelomahyperleukocytosischronic neutrophilic leukemia |
| spellingShingle | I. G. Rekhtina L. Yu. Kolosova V. A. Khyshova A. M. Kovrigina L. P. Mendeleeva Neutrophilic hyperleukocytosis in the multiple myeloma onset Онкогематология multiple myeloma hyperleukocytosis chronic neutrophilic leukemia |
| title | Neutrophilic hyperleukocytosis in the multiple myeloma onset |
| title_full | Neutrophilic hyperleukocytosis in the multiple myeloma onset |
| title_fullStr | Neutrophilic hyperleukocytosis in the multiple myeloma onset |
| title_full_unstemmed | Neutrophilic hyperleukocytosis in the multiple myeloma onset |
| title_short | Neutrophilic hyperleukocytosis in the multiple myeloma onset |
| title_sort | neutrophilic hyperleukocytosis in the multiple myeloma onset |
| topic | multiple myeloma hyperleukocytosis chronic neutrophilic leukemia |
| url | https://oncohematology.abvpress.ru/ongm/article/view/561 |
| work_keys_str_mv | AT igrekhtina neutrophilichyperleukocytosisinthemultiplemyelomaonset AT lyukolosova neutrophilichyperleukocytosisinthemultiplemyelomaonset AT vakhyshova neutrophilichyperleukocytosisinthemultiplemyelomaonset AT amkovrigina neutrophilichyperleukocytosisinthemultiplemyelomaonset AT lpmendeleeva neutrophilichyperleukocytosisinthemultiplemyelomaonset |