Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritis
Abstract Background The EQ-5D-5 L is a quality-of-life questionnaire based on individuals’ preferences that is widely employed for cost-effectiveness analysis. Given the current demand for mapping algorithms to directly assign “utilities”, this study aimed to generate different mapping models for pr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-06-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12955-020-01435-8 |
| _version_ | 1818027743892209664 |
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| author | Jesús Martín-Fernández Mariel Morey-Montalvo Nuria Tomás-García Elena Martín-Ramos Juan Carlos Muñoz-García Elena Polentinos-Castro Gemma Rodríguez-Martínez Juan Carlos Arenaza Lidia García-Pérez Laura Magdalena-Armas Amaia Bilbao |
| author_facet | Jesús Martín-Fernández Mariel Morey-Montalvo Nuria Tomás-García Elena Martín-Ramos Juan Carlos Muñoz-García Elena Polentinos-Castro Gemma Rodríguez-Martínez Juan Carlos Arenaza Lidia García-Pérez Laura Magdalena-Armas Amaia Bilbao |
| author_sort | Jesús Martín-Fernández |
| collection | DOAJ |
| description | Abstract Background The EQ-5D-5 L is a quality-of-life questionnaire based on individuals’ preferences that is widely employed for cost-effectiveness analysis. Given the current demand for mapping algorithms to directly assign “utilities”, this study aimed to generate different mapping models for predicting EQ-5D-5 L utility values based on scores of the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires provided by patients suffering from hip and knee osteoarthritis (OA), respectively, and to assess the predictive capability of these functions. Methods This was a prospective, observational study. Following the criteria of the American Rheumatism Association, 361 patients with hip OA and 397 with knee OA from three regions in Spain were included. Health-related quality of life (HRQoL) was assessed through the EQ-5D-5 L general questionnaire and the OHS and OKS specifically for lower limb OA. Based on the scores on the OHS and OKS questionnaires, EQ-5D-5 L utilities were estimated using 4 models: ordinary least squares (OLS), Tobit, generalized linear model (GLM), and beta regression (Breg). The models were validated on the same patients after 6 months: the mean absolute error (MAE) and mean squared error (MSE) with their 95% confidence intervals (CI), mean values of standard errors (SE), intraclass correlation coefficients (ICC), and Bland-Altman plots were obtained. Results The lowest MAEs were obtained using GLM and Breg models, with values of 0.1103 (0.0993–0.1214) and 0.1229 (0.1102–0.1335) for hip OA, and values of 0.1127 (0.1014–0.1239) and 0.1141 (0.1031–0.1251) for knee OA. MSE values were also lower using GLM and Breg. ICCs between predicted and observed values were around or over the 0.8 cut-off point. Bland-Altman plots showed an acceptable correlation, but precision was lower for subjects with worse HRQoL, which was also evident when comparing MAEs of the bottom and top halves of the utilities scale. Predictive equations for utilities based on OHS/OKS scores were proposed. Conclusions The OHS and OKS scores allow for estimating EQ-5D-5 L utility indexes for patients with hip and knee OA, respectively, with adequate validity and precision. GLM and Breg produce the best predictions. The predictive power of proposed equations is more consistent for subjects in better health condition. |
| first_indexed | 2024-12-10T04:52:45Z |
| format | Article |
| id | doaj.art-cf5f4af2c39642eda3d2e1008564a6bc |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-12-10T04:52:45Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-cf5f4af2c39642eda3d2e1008564a6bc2022-12-22T02:01:35ZengBMCHealth and Quality of Life Outcomes1477-75252020-06-0118111510.1186/s12955-020-01435-8Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritisJesús Martín-Fernández0Mariel Morey-Montalvo1Nuria Tomás-García2Elena Martín-Ramos3Juan Carlos Muñoz-García4Elena Polentinos-Castro5Gemma Rodríguez-Martínez6Juan Carlos Arenaza7Lidia García-Pérez8Laura Magdalena-Armas9Amaia Bilbao10Unidad Docente Multiprofesional de Atención Familiar y Comunitaria Oeste, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de SaludRed de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC)C.S. San Martín de Valdeiglesias, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de SaludC.S. Alcalde Bartolomé González, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de SaludC.S. El Soto. Gerencia Asistencial de Atención Primaria, Servicio Madrileño de SaludRed de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC)C.S. Infante Don Luis, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de SaludOsakidetza, Hospital Universitario Basurto, Servicio de Traumatología y Cirugía OrtopédicaFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC)Hospital Universitario Nuestra Señora de CandelariaRed de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC)Abstract Background The EQ-5D-5 L is a quality-of-life questionnaire based on individuals’ preferences that is widely employed for cost-effectiveness analysis. Given the current demand for mapping algorithms to directly assign “utilities”, this study aimed to generate different mapping models for predicting EQ-5D-5 L utility values based on scores of the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires provided by patients suffering from hip and knee osteoarthritis (OA), respectively, and to assess the predictive capability of these functions. Methods This was a prospective, observational study. Following the criteria of the American Rheumatism Association, 361 patients with hip OA and 397 with knee OA from three regions in Spain were included. Health-related quality of life (HRQoL) was assessed through the EQ-5D-5 L general questionnaire and the OHS and OKS specifically for lower limb OA. Based on the scores on the OHS and OKS questionnaires, EQ-5D-5 L utilities were estimated using 4 models: ordinary least squares (OLS), Tobit, generalized linear model (GLM), and beta regression (Breg). The models were validated on the same patients after 6 months: the mean absolute error (MAE) and mean squared error (MSE) with their 95% confidence intervals (CI), mean values of standard errors (SE), intraclass correlation coefficients (ICC), and Bland-Altman plots were obtained. Results The lowest MAEs were obtained using GLM and Breg models, with values of 0.1103 (0.0993–0.1214) and 0.1229 (0.1102–0.1335) for hip OA, and values of 0.1127 (0.1014–0.1239) and 0.1141 (0.1031–0.1251) for knee OA. MSE values were also lower using GLM and Breg. ICCs between predicted and observed values were around or over the 0.8 cut-off point. Bland-Altman plots showed an acceptable correlation, but precision was lower for subjects with worse HRQoL, which was also evident when comparing MAEs of the bottom and top halves of the utilities scale. Predictive equations for utilities based on OHS/OKS scores were proposed. Conclusions The OHS and OKS scores allow for estimating EQ-5D-5 L utility indexes for patients with hip and knee OA, respectively, with adequate validity and precision. GLM and Breg produce the best predictions. The predictive power of proposed equations is more consistent for subjects in better health condition.http://link.springer.com/article/10.1186/s12955-020-01435-8Quality of lifeHealth statusOsteoarthritisEconomicsCost-benefit analysisEQ-5D |
| spellingShingle | Jesús Martín-Fernández Mariel Morey-Montalvo Nuria Tomás-García Elena Martín-Ramos Juan Carlos Muñoz-García Elena Polentinos-Castro Gemma Rodríguez-Martínez Juan Carlos Arenaza Lidia García-Pérez Laura Magdalena-Armas Amaia Bilbao Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritis Health and Quality of Life Outcomes Quality of life Health status Osteoarthritis Economics Cost-benefit analysis EQ-5D |
| title | Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritis |
| title_full | Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritis |
| title_fullStr | Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritis |
| title_full_unstemmed | Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritis |
| title_short | Mapping analysis to predict EQ-5D-5 L utility values based on the Oxford Hip Score (OHS) and Oxford Knee Score (OKS) questionnaires in the Spanish population suffering from lower limb osteoarthritis |
| title_sort | mapping analysis to predict eq 5d 5 l utility values based on the oxford hip score ohs and oxford knee score oks questionnaires in the spanish population suffering from lower limb osteoarthritis |
| topic | Quality of life Health status Osteoarthritis Economics Cost-benefit analysis EQ-5D |
| url | http://link.springer.com/article/10.1186/s12955-020-01435-8 |
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