Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob disease
<p><strong>Objective</strong> To explore the diagnostic value of diffusion-weighted imaging (DWI) on sporadic Creutzfeldt-Jakob disease (sCJD). <strong>Methods </strong> The MRI findings of 21 patients with clinically proved probable sCJD were analyzed retrospective...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2014-04-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/934 |
| _version_ | 1818127903431327744 |
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| author | Yan-hui YANG Sheng-chao ZHANG Cheng XU Kun-cheng LI |
| author_facet | Yan-hui YANG Sheng-chao ZHANG Cheng XU Kun-cheng LI |
| author_sort | Yan-hui YANG |
| collection | DOAJ |
| description | <p><strong>Objective</strong> To explore the diagnostic value of diffusion-weighted imaging (DWI) on sporadic Creutzfeldt-Jakob disease (sCJD). <strong>Methods </strong> The MRI findings of 21 patients with clinically proved probable sCJD were analyzed retrospectively and the characteristics were summarized especially in DWI. <strong>Results</strong> 1) All 21 cases of sCJD were shown abnormal in DWI, which appeared as linear hyperintensity signals in cerebral cortex and patchy hyperintensity in caudate nucleus and (or) lenticular nucleus. 2) The abnormal signals were most commonly seen in cerebral cortex accompanied with the basal ganglia (16 cases, 76.19%). Besides, there were 3 cases of cortex involvement (14.29%) and 2 cases of basal ganglia involvement (9.52% ). Among the lesions in cerebral cortex, the frontal and parietal lobes were affected more commonly (15 cases, 78.95%; 13 cases, 68.42%) than the temporal and occipital lobes (12 cases, 63.16%; 9 cases, 47.37%). 3) DWI was superior to T<sub>1</sub>WI, T<sub>2</sub>WI and FLAIR imaging sequences. The abnormal signals in DWI were accompanied by decreased apparent diffusion coefficient (ADC) values. 4) During the follow-up in 5 patients, the range and intensity of high signal changed in DWI, and only one case presented reduced range of abnormal signal.<strong> Conclusions </strong> sCJD manifests characteristic changes on DWI, which should be suggested as an essential tool for diagnosing sCJD.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.04.010</p> |
| first_indexed | 2024-12-11T07:24:45Z |
| format | Article |
| id | doaj.art-cf5fb0bb4e774279b41f21618bc89072 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-11T07:24:45Z |
| publishDate | 2014-04-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-cf5fb0bb4e774279b41f21618bc890722022-12-22T01:16:00ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312014-04-01144316321933Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob diseaseYan-hui YANG0Sheng-chao ZHANG1Cheng XU2Kun-cheng LI3Department of Radiology, Xuanwu Hospital, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing 100053, ChinaDepartment of Medical Imaging, Shanxi Province People's Hospital, Taiyuan 030012, Shanxi, ChinaDepartment of Medical Imaging, Shanxi Province People's Hospital, Taiyuan 030012, Shanxi, ChinaDepartment of Radiology, Xuanwu Hospital, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing 100053, China<p><strong>Objective</strong> To explore the diagnostic value of diffusion-weighted imaging (DWI) on sporadic Creutzfeldt-Jakob disease (sCJD). <strong>Methods </strong> The MRI findings of 21 patients with clinically proved probable sCJD were analyzed retrospectively and the characteristics were summarized especially in DWI. <strong>Results</strong> 1) All 21 cases of sCJD were shown abnormal in DWI, which appeared as linear hyperintensity signals in cerebral cortex and patchy hyperintensity in caudate nucleus and (or) lenticular nucleus. 2) The abnormal signals were most commonly seen in cerebral cortex accompanied with the basal ganglia (16 cases, 76.19%). Besides, there were 3 cases of cortex involvement (14.29%) and 2 cases of basal ganglia involvement (9.52% ). Among the lesions in cerebral cortex, the frontal and parietal lobes were affected more commonly (15 cases, 78.95%; 13 cases, 68.42%) than the temporal and occipital lobes (12 cases, 63.16%; 9 cases, 47.37%). 3) DWI was superior to T<sub>1</sub>WI, T<sub>2</sub>WI and FLAIR imaging sequences. The abnormal signals in DWI were accompanied by decreased apparent diffusion coefficient (ADC) values. 4) During the follow-up in 5 patients, the range and intensity of high signal changed in DWI, and only one case presented reduced range of abnormal signal.<strong> Conclusions </strong> sCJD manifests characteristic changes on DWI, which should be suggested as an essential tool for diagnosing sCJD.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.04.010</p>http://www.cjcnn.org/index.php/cjcnn/article/view/934Creutzfeld-Jakob syndromeMagnetic resonance imaging |
| spellingShingle | Yan-hui YANG Sheng-chao ZHANG Cheng XU Kun-cheng LI Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob disease Chinese Journal of Contemporary Neurology and Neurosurgery Creutzfeld-Jakob syndrome Magnetic resonance imaging |
| title | Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob disease |
| title_full | Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob disease |
| title_fullStr | Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob disease |
| title_full_unstemmed | Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob disease |
| title_short | Diagnostic value of diffusion-weighted imaging on sporadic Creutzfeldt-Jakob disease |
| title_sort | diagnostic value of diffusion weighted imaging on sporadic creutzfeldt jakob disease |
| topic | Creutzfeld-Jakob syndrome Magnetic resonance imaging |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/934 |
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