Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study.
BACKGROUND: Substantial evidence suggests that increased oxidative stress in hemodialysis (HD) patients may contribute to cardiovascular complications. Oxidative modifications of human serum albumin (HSA), the largest thiol pool in plasma, alter its biological properties and may affect its antioxida...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3726598?pdf=render |
| _version_ | 1811230143068241920 |
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| author | Paik Seong Lim Yachung Jeng Ming Ying Wu Mei-Ann Pai Tsai-Kun Wu Chia-San Liu Chan Hsu Chen Yuan-Chuan Kuo Shiaw-Wen Chien Hung Ping Chen |
| author_facet | Paik Seong Lim Yachung Jeng Ming Ying Wu Mei-Ann Pai Tsai-Kun Wu Chia-San Liu Chan Hsu Chen Yuan-Chuan Kuo Shiaw-Wen Chien Hung Ping Chen |
| author_sort | Paik Seong Lim |
| collection | DOAJ |
| description | BACKGROUND: Substantial evidence suggests that increased oxidative stress in hemodialysis (HD) patients may contribute to cardiovascular complications. Oxidative modifications of human serum albumin (HSA), the largest thiol pool in plasma, alter its biological properties and may affect its antioxidant potential in HD patients. METHODS: We conducted a long-term follow-up study in a cohort of normoalbuminemic HD patients to examine the impact of redox state of serum albumin on patients' survival by measuring the human nonmercaptoalbumin (HNA) fraction of HSA. RESULTS: After adjusting for potential demographic, anthropometric, and clinical confounders, a positive association of HNA level with the risk of death from cardiovascular disease (CVD) and all-cause mortality was observed in normoalbuminemic HD patients. Using stratified analysis, we found a stronger association between HNA level and the risk of death from CVD and all-cause mortality in patients with pre-existing CVD. CONCLUSIONS: Serum HNA level is a positive predictor of mortality in normoalbuminemic HD patients, especially among those with pre-existing CVD. Increased oxidative stress resulting from biological changes in serum albumin levels could contribute to accelerated atherosclerosis and the development of cardiovascular disease in HD patients. |
| first_indexed | 2024-04-12T10:25:20Z |
| format | Article |
| id | doaj.art-cf6099f5868a410b9392768b3cb9177a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T10:25:20Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cf6099f5868a410b9392768b3cb9177a2022-12-22T03:36:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e7082210.1371/journal.pone.0070822Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study.Paik Seong LimYachung JengMing Ying WuMei-Ann PaiTsai-Kun WuChia-San LiuChan Hsu ChenYuan-Chuan KuoShiaw-Wen ChienHung Ping ChenBACKGROUND: Substantial evidence suggests that increased oxidative stress in hemodialysis (HD) patients may contribute to cardiovascular complications. Oxidative modifications of human serum albumin (HSA), the largest thiol pool in plasma, alter its biological properties and may affect its antioxidant potential in HD patients. METHODS: We conducted a long-term follow-up study in a cohort of normoalbuminemic HD patients to examine the impact of redox state of serum albumin on patients' survival by measuring the human nonmercaptoalbumin (HNA) fraction of HSA. RESULTS: After adjusting for potential demographic, anthropometric, and clinical confounders, a positive association of HNA level with the risk of death from cardiovascular disease (CVD) and all-cause mortality was observed in normoalbuminemic HD patients. Using stratified analysis, we found a stronger association between HNA level and the risk of death from CVD and all-cause mortality in patients with pre-existing CVD. CONCLUSIONS: Serum HNA level is a positive predictor of mortality in normoalbuminemic HD patients, especially among those with pre-existing CVD. Increased oxidative stress resulting from biological changes in serum albumin levels could contribute to accelerated atherosclerosis and the development of cardiovascular disease in HD patients.http://europepmc.org/articles/PMC3726598?pdf=render |
| spellingShingle | Paik Seong Lim Yachung Jeng Ming Ying Wu Mei-Ann Pai Tsai-Kun Wu Chia-San Liu Chan Hsu Chen Yuan-Chuan Kuo Shiaw-Wen Chien Hung Ping Chen Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study. PLoS ONE |
| title | Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study. |
| title_full | Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study. |
| title_fullStr | Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study. |
| title_full_unstemmed | Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study. |
| title_short | Serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients: a cohort study. |
| title_sort | serum oxidized albumin and cardiovascular mortality in normoalbuminemic hemodialysis patients a cohort study |
| url | http://europepmc.org/articles/PMC3726598?pdf=render |
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