Liver aquaporins: Significance in canalicular and ductal bile formation
Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the ve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2004-10-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119320903 |
| _version_ | 1819108168987312128 |
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| author | Raúl A. Marinelli Sergio A. Gradilone Flavia I. Carreras Giuseppe Calamita Guillermo L. Lehmann |
| author_facet | Raúl A. Marinelli Sergio A. Gradilone Flavia I. Carreras Giuseppe Calamita Guillermo L. Lehmann |
| author_sort | Raúl A. Marinelli |
| collection | DOAJ |
| description | Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions. |
| first_indexed | 2024-12-22T03:05:39Z |
| format | Article |
| id | doaj.art-cf612e23a2cd4302810b4ff18c58f145 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-22T03:05:39Z |
| publishDate | 2004-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-cf612e23a2cd4302810b4ff18c58f1452022-12-21T18:41:04ZengElsevierAnnals of Hepatology1665-26812004-10-0134130136Liver aquaporins: Significance in canalicular and ductal bile formationRaúl A. Marinelli0Sergio A. Gradilone1Flavia I. Carreras2Giuseppe Calamita3Guillermo L. Lehmann4Instituto de Fisiología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, 2000 Rosario, Santa Fe, Argentina; Address for correspondence:Instituto de Fisiología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, 2000 Rosario, Santa Fe, ArgentinaInstituto de Fisiología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, 2000 Rosario, Santa Fe, ArgentinaDipartimento di Fisiologia Generale ed Ambientale, Università degliStudi di Bari, 70126 Bari, ItalyInstituto de Fisiología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, 2000 Rosario, Santa Fe, ArgentinaBile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.http://www.sciencedirect.com/science/article/pii/S1665268119320903Water channelshepatocytescholangiocytes |
| spellingShingle | Raúl A. Marinelli Sergio A. Gradilone Flavia I. Carreras Giuseppe Calamita Guillermo L. Lehmann Liver aquaporins: Significance in canalicular and ductal bile formation Annals of Hepatology Water channels hepatocytes cholangiocytes |
| title | Liver aquaporins: Significance in canalicular and ductal bile formation |
| title_full | Liver aquaporins: Significance in canalicular and ductal bile formation |
| title_fullStr | Liver aquaporins: Significance in canalicular and ductal bile formation |
| title_full_unstemmed | Liver aquaporins: Significance in canalicular and ductal bile formation |
| title_short | Liver aquaporins: Significance in canalicular and ductal bile formation |
| title_sort | liver aquaporins significance in canalicular and ductal bile formation |
| topic | Water channels hepatocytes cholangiocytes |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119320903 |
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