Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats
Neoplasms of melanocytic origin are diseases relevant to dogs and cats’ ophthalmic oncology due to their incidence, potential visual loss, and consequent decrease in life quality and expectancy. Despite its non-specific clinical presentation, melanocytic neoplasms can be histologically distinguished...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/8/12/225 |
| _version_ | 1797506618036846592 |
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| author | Tarcísio Guerra Guimarães Karla Menezes Cardoso Pedro Tralhão Carlos Miguel Marto Nuno Alexandre Maria Filomena Botelho Mafalda Laranjo |
| author_facet | Tarcísio Guerra Guimarães Karla Menezes Cardoso Pedro Tralhão Carlos Miguel Marto Nuno Alexandre Maria Filomena Botelho Mafalda Laranjo |
| author_sort | Tarcísio Guerra Guimarães |
| collection | DOAJ |
| description | Neoplasms of melanocytic origin are diseases relevant to dogs and cats’ ophthalmic oncology due to their incidence, potential visual loss, and consequent decrease in life quality and expectancy. Despite its non-specific clinical presentation, melanocytic neoplasms can be histologically distinguished in melanocytomas, which present benign characteristics, and malignant melanomas. The diagnosis often occurs in advanced cases, limiting the therapeutic options. Surgery, cryotherapy, radiotherapy, photodynamic therapy (PDT), and laser are currently available therapeutic strategies. As no clinical guidelines are available, the treatment choice is primarily based on the clinician’s preference, proficiency, and the owner’s financial constraints. While surgery is curative in benign lesions, ocular melanomas present a variable response to treatments, besides the potential of tumour recurrences or metastatic disease. This review presents the currently available therapies for ocular melanocytic neoplasms in dogs and cats, describing the therapeutic, indications, and limitations. Additionally, new therapeutics being developed are presented and discussed, as they can improve the current treatment options. |
| first_indexed | 2024-03-10T04:35:06Z |
| format | Article |
| id | doaj.art-cf61474dd106439fb7a8a1b9ddcbd55e |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T04:35:06Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-cf61474dd106439fb7a8a1b9ddcbd55e2023-11-23T03:52:35ZengMDPI AGBioengineering2306-53542021-12-0181222510.3390/bioengineering8120225Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and CatsTarcísio Guerra Guimarães0Karla Menezes Cardoso1Pedro Tralhão2Carlos Miguel Marto3Nuno Alexandre4Maria Filomena Botelho5Mafalda Laranjo6Institute of Research and Advanced Training (IIFA), University of Évora, 7002-554 Évora, PortugalInstitute of Research and Advanced Training (IIFA), University of Évora, 7002-554 Évora, PortugalCenter of Veterinary Ophthalmology, Oftalvet, 4050-102 Porto, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalMediterranean Institute for Agriculture, Environment and Development (MED), University of Évora, 7006-554 Évora, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalInstitute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, PortugalNeoplasms of melanocytic origin are diseases relevant to dogs and cats’ ophthalmic oncology due to their incidence, potential visual loss, and consequent decrease in life quality and expectancy. Despite its non-specific clinical presentation, melanocytic neoplasms can be histologically distinguished in melanocytomas, which present benign characteristics, and malignant melanomas. The diagnosis often occurs in advanced cases, limiting the therapeutic options. Surgery, cryotherapy, radiotherapy, photodynamic therapy (PDT), and laser are currently available therapeutic strategies. As no clinical guidelines are available, the treatment choice is primarily based on the clinician’s preference, proficiency, and the owner’s financial constraints. While surgery is curative in benign lesions, ocular melanomas present a variable response to treatments, besides the potential of tumour recurrences or metastatic disease. This review presents the currently available therapies for ocular melanocytic neoplasms in dogs and cats, describing the therapeutic, indications, and limitations. Additionally, new therapeutics being developed are presented and discussed, as they can improve the current treatment options.https://www.mdpi.com/2306-5354/8/12/225melanocytic neoplasmsmelanomatherapeutics |
| spellingShingle | Tarcísio Guerra Guimarães Karla Menezes Cardoso Pedro Tralhão Carlos Miguel Marto Nuno Alexandre Maria Filomena Botelho Mafalda Laranjo Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats Bioengineering melanocytic neoplasms melanoma therapeutics |
| title | Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats |
| title_full | Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats |
| title_fullStr | Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats |
| title_full_unstemmed | Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats |
| title_short | Current Therapeutics and Future Perspectives to Ocular Melanocytic Neoplasms in Dogs and Cats |
| title_sort | current therapeutics and future perspectives to ocular melanocytic neoplasms in dogs and cats |
| topic | melanocytic neoplasms melanoma therapeutics |
| url | https://www.mdpi.com/2306-5354/8/12/225 |
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