Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017
Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society–appointed task force of eight experts, a methodologist, and a medical writer. Evidence: This evidence-based...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Publishing House TRILIST
2017-12-01
|
| Series: | Репродуктивная эндокринология |
| Subjects: | |
| Online Access: | http://reproduct-endo.com/article/view/119834 |
| _version_ | 1811333849284608000 |
|---|---|
| author | Catherine M. Gordon Kathryn E. Ackerman Sarah L. Berga |
| author_facet | Catherine M. Gordon Kathryn E. Ackerman Sarah L. Berga |
| author_sort | Catherine M. Gordon |
| collection | DOAJ |
| description | Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA).
Participants: The participants include an Endocrine Society–appointed task force of eight experts, a methodologist, and a medical writer.
Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies.
Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline.
Conclusions: FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. The term “functional” implies that correction or amelioration of causal behavioral factors will restore ovulatory ovarian function. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation. As part of an initial endocrine evaluation for patients with FHA, we recommend obtaining the following laboratory tests: serum thyroid-stimulating hormone, free thyroxine, prolactin, luteinizing hormone, follicle-stimulating hormone, estradiol, and antiMullerian hormone. |
| first_indexed | 2024-04-13T16:58:57Z |
| format | Article |
| id | doaj.art-cf6482f0f2934ff992135e30011c7090 |
| institution | Directory Open Access Journal |
| issn | 2309-4117 2411-1295 |
| language | English |
| last_indexed | 2024-04-13T16:58:57Z |
| publishDate | 2017-12-01 |
| publisher | Publishing House TRILIST |
| record_format | Article |
| series | Репродуктивная эндокринология |
| spelling | doaj.art-cf6482f0f2934ff992135e30011c70902022-12-22T02:38:44ZengPublishing House TRILISTРепродуктивная эндокринология2309-41172411-12952017-12-0138132110.18370/2309-4117.2017.38.13-21111150Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017Catherine M. Gordon0Kathryn E. Ackerman1Sarah L. Berga2Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United StatesBoston Children’s Hospital, Massachusetts General Hospital, Boston, Massachusetts, United StatesWake Forest School of Medicine, Winston-Salem, North Carolina, United StatesObjective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society–appointed task force of eight experts, a methodologist, and a medical writer. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies. Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline. Conclusions: FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. The term “functional” implies that correction or amelioration of causal behavioral factors will restore ovulatory ovarian function. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation. As part of an initial endocrine evaluation for patients with FHA, we recommend obtaining the following laboratory tests: serum thyroid-stimulating hormone, free thyroxine, prolactin, luteinizing hormone, follicle-stimulating hormone, estradiol, and antiMullerian hormone.http://reproduct-endo.com/article/view/119834the american society for reproductive medicinethe european society of endocrinologyand the pediatric endocrine society. this guideline was funded by the endocrine society. |
| spellingShingle | Catherine M. Gordon Kathryn E. Ackerman Sarah L. Berga Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017 Репродуктивная эндокринология the american society for reproductive medicine the european society of endocrinology and the pediatric endocrine society. this guideline was funded by the endocrine society. |
| title | Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017 |
| title_full | Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017 |
| title_fullStr | Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017 |
| title_full_unstemmed | Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017 |
| title_short | Functional hypothalamic amenorrhea: аn endocrine society clinical practice guideline, 2017 |
| title_sort | functional hypothalamic amenorrhea аn endocrine society clinical practice guideline 2017 |
| topic | the american society for reproductive medicine the european society of endocrinology and the pediatric endocrine society. this guideline was funded by the endocrine society. |
| url | http://reproduct-endo.com/article/view/119834 |
| work_keys_str_mv | AT catherinemgordon functionalhypothalamicamenorrheaanendocrinesocietyclinicalpracticeguideline2017 AT kathryneackerman functionalhypothalamicamenorrheaanendocrinesocietyclinicalpracticeguideline2017 AT sarahlberga functionalhypothalamicamenorrheaanendocrinesocietyclinicalpracticeguideline2017 |